NSG552/NSG 552 PSYCHOPHARMACOLOGY EXAM 1
ACTUAL EXAM COMPLETE 91 QUESTIONS AND
CORRECT DETAILED ANSWERS (VERIFIED ANSWERS)
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CYP450 ✔✔CORRECT ANSWER✔✔A group of enzymes in the liver that
metabolize different drugs. There are six.
List the 7 CYP450 Enzymes ✔✔CORRECT ANSWER✔✔(1) CYP1A2
(2) CYP2B6
(3) CYP2C9
(4) CYP2C19
(5) CYP2D6
(6) CYP3A4
(7) CYP2EI
CYP2B6 ✔✔CORRECT ANSWER✔✔Metabolizes arteminsin, bupropion,
cyclophosphamide, efavirenz, ketamine, and methadone (2B6, there are two
psych drugs (bupropion, methadone (ketamine...?) and six altogether.
,CYP2C19 ✔✔CORRECT ANSWER✔✔metabolizes PPIs, antidepressants,
antiplatelet, antifungals, and anticancer drugs (2C19, two see one, there is
only one class of psych drugs that are metabolized, you ONLY SEE one!
antidepressants)
CYP2D6 ✔✔CORRECT ANSWER✔✔Metabolizes Cardiovascular drugs (2-D
echo, echo is a test for heart)
CYP3A4 ✔✔CORRECT ANSWER✔✔Most common and ambiguous (if not
above, then it's this one, a lot of psych drugs are involved with this one)
CYP2EI ✔✔CORRECT ANSWER✔✔ETOH (You have to be 21 to drink)
CYP450 inhibitors ✔✔CORRECT ANSWER✔✔Decreases drug metabolism:
(1) Valproate
(2) Ketoconazole
(3) Isoniazid
(4) Sulfonamides
(5) Chloramphenicol
(6) Amiodarone
(7) All macrolides (think mycins) except azithromycin
(8) Quinidine
(9) Grapefruit juice
Mesolimbic pathway ✔✔CORRECT ANSWER✔✔Increase in dopamine in this
pathway causes positive symptoms
Tuberoinfundibular pathway ✔✔CORRECT ANSWER✔✔Increase in
dopamine in this pathway causes hypoprolactinemia
Mesocortical pathway ✔✔CORRECT ANSWER✔✔Decrease in dopamine
activity can cause negative, cognitive, and affective symptoms
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