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D027 WGU pathopharm Exam with Questions and Answers| Latest Update | Verified Answers
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D027 WGU pathopharm Exam with Questions and Answers| Latest Update | Verified Answers
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D027 WGU pathopharm Exam with Questionsand Answers| Latest Update | Verified Answers
Which medication may hide symptoms of hypoglycemia in a patient with T1DM? - ✔✔beta
blockers
Example of Antiplatelet drug - ✔✔clopidogrel (plavix)
MOA of anti-platelet drug - ✔✔inhibits fxn of ADP by blocking receptor site on platelet
adverse drug reactions to clopidogrel/Plavix - ✔✔bruising, bleeding, rash, flulike sx
CAUTION with clopidogrel - ✔✔avoid ASA/Plavix/ NSAIDS
- stop taking at least 5 days prior to surgery
example of indirect thrombin inhibitor - ✔✔heparin, enoxoparin, dalteparin
- parins
MOA of heparin - ✔✔inhibits factor 10 (X) and therefor inhibits thrombin formation
- fast acting, short 1/2 life
Antedote for heparin - ✔✔protamine sulfate
Lab value evaluated for heparin - ✔✔aPTT (activated partial thrombine time)
- looking for 1.5-2.5 x the normal value- so if normal is 25-35 seconds, look for 60-90 seconds
,what factors do vitamin k antagonists effect? - ✔✔9a, 7a, 10a, and prothrombin
- decreases fibrin clot formation
what is an example of a vitamin K antagonist - ✔✔Warfarin (Coumadin)
What interactions does Warfarin Have? - ✔✔anything that contains vitamin K : the "G"
herbal products (Ginko, Green tea, Ginseng, Ginger)
dark leafy greens
Antidote for excessive bleeding caused by warfarin - ✔✔vitamin K injection
- effects may be delayed 2-7 days due to the delayed onset
Labs evaluated with warfarin - ✔✔INR 2-4 range
PT in combination- 9-12 seconds
examples of direct factor X inhibitors - ✔✔- xaban
Rivaroxaban (Xarelto) and Apixaban (Eliquis)
antedote for direct factor 10 inhibitors - ✔✔none FDa approved, but andexanet alfa
benefts of eliquis/lovenox over coumadin - ✔✔less food/drug interactions
labs not required when initiating
example of thrombolytic agent - ✔✔alteplase
Alteplase MOA - ✔✔Convers plasminogen to plasmin
-plasmin dissolves fibrin clots
, -used for acute MI or strokes
- also used off label to dissolve clot in IV lines
Which Items should be avoided if a patient is taking wafarin sodium after experiencing a heart
attack?
a) prunes
b) spinach
c) green tea
d) white rice
e) kale - ✔✔a, b, c, e
- counteracts effects vitamin K
When injecting heparin, which of the following are correct practices to minimize adverse effects
of this drug? SATA
a) IM
b) massage injection site
c) no aspiration
d) parenteral
e) aptt measures heparin efficacy - ✔✔c) d) e)
A pediatric patient diagnosed with Kawasaki's disease requires antiplatelet therapy. Which one
of the following medications is appropriate for this patient?
a) aspirin
b) coumadin
c) alteplase
d) enoxaparin
e) edoxaban - ✔✔aspirin
- benefits outweigh risk even though it can cause Reye syndrome
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