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HTHSCI 3I03 Final Exam questions with correct answers
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HTHSCI 3I03 Final Exam questions with correct answers
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1-232 of 232Does not activate complement effectively, resistant to proteases
IgA Virtues for Mucosal Secretions
,CD45 is spliced to CD45RO which makes memory and effector T cells work more
effectively with coreceptors and activate more readily
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CD45 in Memory T Cells
IgG > IgM, Requires T Cell help for activation, SHM and Memory. Very diverse and
found in secondary lymphoid organs
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B2 Cells
can be used to treat c. defficile, irritable bowel syndrome, and correct metabolic
disorders
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Fecal transplation
Neutrophils commit cell death releasing chromatin as nets containing granules to trap
microbes
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, Netosis
Inhibited by IL-4, IFN-gamma, TGF-B
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IgM Isotype Switch
Redness, Heat, Swelling, Pain
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Inflammation
Activated CD4 T Cells recognize antigen from APC, produces IL-2, upregulates
CD40L to activate APC and upregulate costimulatory signals in APC, Costimulatory
signal fully activates interacting CD8 T cell
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Crosstalk
Typically carbohydrates
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, Thymus independent Antigens
Occurs of antibody heavy chain and TCR heavy chains
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VDJ recombination
Can lead to Disseminated Intravascular Coagulation that can result in multiple organ
failure and ultimately death
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Systemic inflammation
1-10 for humans, 1-9 and 11 for mice
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TLRs
Acidification of vesicles of extracellular antigen breaks them down to small peptides.
MHC II stabilized with invariant chain that prevents binding of endogenous proteins.
Endosome arrivale leaves invariant chain leaving clip in binding cleft. HLA-DM
releases clip from binding cleft and lets peptide fragments in endosomes to compete
and bind to MHC II binding cleft
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