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Exam (elaborations)

Part 3 of HTHSCI 3I03 questions with 100% correct answers

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  • HTHSCI 3I03
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  • HTHSCI 3I03

Part 3 of HTHSCI 3I03 questions with 100% correct answers

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  • October 3, 2024
  • 22
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • HTHSCI 3I03
  • HTHSCI 3I03
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codersimon
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What is rituximab?


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anti CD20 IgG mAB, kill B cells

,Explain how inhaled allergens lead to an immune response?


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Inhaled, APC capture and present to Th2, get IgE response




What do macrophages form as a defense? What does this benefit


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granuloma
protect both host and Mtb; host- control, Mtb: IS weak in the granuloma




What are adjuvants? Examples


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Enhance immune resp to the vaccine bcs vaccines trigger a weaker
response than infection
aluminum, oil in water, TLR agonist




Macrophage/monocyte markers


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, CD14




Parasitic and allergen receptors on Mast and B cells


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B cells make IgE specific for allergen or parasite
- mast cell passively acquire IgE with different specificity that bind to
FcERi- cross link = degranualte




Why is Mtb good at evading the host IS? How does it do that?


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Mtb suppresses immune activation
- long TNF response, long time for DC to go to the site of infection
- inhibit IL-12 resulting in slow T cell priming and T cell recruitment




How are there still low levels of pathogen specific antibodies after the primary
infection?


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Maintained via long lived plasma cells
- survival via interaction with IL-6 and BM stromal cells
- or die if interact with FCRs --> apoptosis

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