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Summary - HTHSCI 3I03|HTHSCI 3I03 - Midterm 1 Notes
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HTHSCI 3I03 - Midterm 1 Notes
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1-137 of 137Necrosis
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, - Not immunogenic
- Mass cell death of a specific tissue or organ
- inflammatory cell death
- DAMPs released
- inflammation cascade signaled
What are the results of the complement system?
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- C3a recruits lots of inflammatory signals
- C3b acts as an opsonin to trigger phagocytosis of pathogen
- C3b causes formation of membrane attack complex (MAC) which
perforates cell membrane
- DEATH OF PATHOGEN
What are the 4 components of innate immunity?
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1) Macrophages
2) Neutrophils
3) Eosinophils
4) Natural Killer cells
What is an antigen presenting cell in the context of MHC Class 1? Class 2?
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, - Any nucleated cells express MHC class 1
- Professional APC only for class 2 (Ex. dendritic cell)
What is Necroptosis?
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- inflammatory cell death
- DAMPs released
What are the two functions of innate immune cells under the skin and mucosal
surfaces?
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1) Immediately capture and kill invading pathogen
2) recognize pathogen and lead to induced immune system
What are the three types of NK cells?
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1) killer (cytotoxic)
2) healer (tissue remodeling)
- help remodel blood vessels to baby during pregnancy
3) IFN-gamma producing
, What is the antimicrobial relevance of keratinized upper cell layer?
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- VIRUSES require receptors to infect and fusion with a LIVE host!
- this property DOES NOT apply to bacteria!
Why do NK cells not kill RBCs?
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- no MHC so do not produce any inhibitory signal BUT
- do not produce any activating signal either unless infected
What is HLA? What are three human Class 1 MHC and 3 human class 2 MHC?
What is special about class 2 (affects naming)
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Human Leukocyte Agent
Class 1: HLA-A, -B, -C
Class 2: HLA-DR, -DP, -DQ
Class 2 is coded by 2 genes since it has 2 polypeptides
What happens if you lack innate vs adaptive immunity?
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