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Questions and answers for HTHSCI 3I03: T cell Regulation and Memory
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Questions and answers for HTHSCI 3I03: T cell Regulation and Memory
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1-27 of 27Describe the process of TCR degeneracy.
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, Upon infection with pathogen 1, both T cells specific for pathogen 1 and
auto-reactive T cells that recognize pathogen 1 proliferate. During
contraction, the number of both decreases. Under normal conditions once
infection is cleared, peripheral tolerance persists and only T cells specific
for pathogen 1 are present. These specific T cells allow memory of the
pathogen.
Why must TCR degeneracy occur?
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T cells compete for nutrients, so T cells that are not actively engaged in the
immune response are disadvantaged simply because they are not needed.
What T cells are actively deleted after resolution of infection?
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Auto-reactive T cells
How many peripheral T cells express 2 TCRs?
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Estimated 30%
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