NUR 641E Exam 3 (MIDTERM)2024/2025
fully solved & updated
What are indications for anticoagulants? - ANSWER-MI, unstable angina, atrial
fibrillation, indwelling devices (mech heart valve) major orthopedic surgery or
prolonged periods of immobilization or long plane rides, strokes..
What are contraindications for anticoagulants? - ANSWER-Known drug allergy
thrombocytopenia
Pregnancy (Warfarin)
Indwelling epidural catheter (LMWH) d/t link with epidural hematoma
What are adverse rxns with Anticoagulants? - ANSWER-Most common:
BLEEDING (localized or systemic) for all anticoagulants!
Heparin induced thrombocytopenia (HIT)
nausea, vomiting, abdominal cramps, thrombocytopenia, bruises
Route and procedures for anticoagulation therapy - ANSWER-Oral and parenteral
(Injection/IV)
Why is Heparin used for anticoagulation? - ANSWER-Preventative, heparin either
unfractionated or low molecular weight (subcutaneous -lovenox) Both can be
used as preventative and DVT treatment
It works faster than Warfarin/Coumadin.
Can be given subQ or IV
What labwork is needed to monitor pts on Heparins - ANSWER-Heparin =
activated PTT every 6 hrs or so, 2-3 days check a CBC d/p for platelet values.
LMWHeparins = none
,What is special about the low molecular weight Heparin - ANSWER-They are more
predictable because they are specific for activated factor Xa. Greater
bioavailability longer elimination half life than unfractionated.
What are the reversal drugs for warfarin and Heparin? - ANSWER-Warfarin = Vit K
Heparin = Protamine sulfate
Heparin (pg 631 in drug guide) - ANSWER-Given parenteral
Preg category C
Short half life (1-2 hours)
Low molecular weights: Preg category B
Lovenox: Don't give inj near umbilicus
don't require labwork
DONT rub injection sites - could cause bruising
Know about how Coumadin (Warfarin) works for anticoagulation - ANSWER-
Inhibits Vit K dependent clotting factors II, VII, IX, and X. Used for clot prevention.
Given PO
Important teaching for Heparin - ANSWER-Regular lab testing
Sx of abnormal bleeding
Wear a medical alert bracelet
Use soft toothbrushes to prevent gum bleeding. watch for nose bleeds, bloody
dark stools, can make nauseous
Monitoring lab work for Coumadin? - ANSWER-Coumadin, PT / INR
PT typically 11-13 seconds, therapeutic is 18 seconds
pts not on anticoagulants typically have INR value of 2-3
pts on warfarin/Coumadin value is 2 to 3.5 with a target of 3
What are the Therapeutic Levels, INR, aPTT, PT? - ANSWER-
, Coumadin (pg 1273 in drug guide) - ANSWER-Given orally only
Preg category X
Monitored by PT INR
Genetic factors alter metabolism of drug
Coumadin adverse effects - ANSWER-Bleeding, lethargy, muscle pain, purple
toes (hands and feet)
Report signs of bleeding/bruising
Avoid alcohol/OTC or herbal products, aspirin, NSAIDs, etc, prior to talking to a
health care professional
Emphasize importance of routine labwork (PT/INR)
Important teaching for Coumadin - ANSWER-Avoid excess amounts of foods with
high Vit K, ie leafy greens, maintain a consistent intake
What is the purpose, risk, and adverse effects of thrombolytic (lysing clots)
therapy - ANSWER-Purpose to break down already existing clots
Adverse/risk: BLEEDING
They're not fibrin specific
Can induce a systemic thrombolytic state instead of focusing on the specific
clots
Internal, intracranial, or superficial bleeding
Anemia
Nausea
Vomiting
hypotension
cardiac dysrhythmias
Protamine Sulfate (page 1044 in drug guide) - ANSWER-Antidote for Heparin
toxicity
Typically 1 mg good to reverse up to 100 units unfractionated Heparin
1 mg needed per 1mg of enoxaparin, dose directly proportional.
What are Protamine sulfate adverse effects? - ANSWER-Bleeding
Anaphylaxis
angioedema
pulmonary edema
bradycardia
dyspnea
pulmonary HTN
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