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Bile Acid Sequestrants Questions and Answers
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Bile Acid Sequestrants Questions and Answers Lopid - Gemfibrozil Tricor - Fenofibrate (Lopid) is a fibric acid derivative.(Tricor) is a fibric acid derivative. Simvastatin (Zocor) is a statin drug. Atorvastatin (Lipitor) is a statin drug. Rosuvastatin (Crestor) is a statin drug. Fibrates a...

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  • October 2, 2024
  • 12
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

Subjects

  • bile acid sequestrants questions and answers
  • lopid gemfibrozil tricor fenofibrate lopid
  • triglyceride levels fibric acid drugs primarily

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Bile Acid Sequestrants Questions and
Answers
Lopid - Gemfibrozil
Tricor - Fenofibrate

(Lopid) is a fibric acid derivative.(Tricor) is a fibric acid derivative.

Simvastatin (Zocor) is a statin drug. Atorvastatin (Lipitor) is a statin drug. Rosuvastatin
(Crestor) is a statin drug. - answer Fibrates are known by which trade names?

Lopid
Tricor
Zocor
Lipitor
Crestor

Triglyceride levels - Fibric acid drugs primarily affect the triglyceride levels.


Total cholesterol- Fibric acid drugs may have an effect on lowering total cholesterol but
this is not the primary action.

LDL cholesterol - Fibric acid drugs may lower the LDL cholesterol but primarily affect
triglyceride levels.

HDL cholesterol - Fibric acid drugs may raise the HDL cholesterol but this is not the
primary action. - answer What do fibric acid derivatives primarily affect?

Triglyceride levels-Correct Answer
Total cholesterol
LDL cholesterol
HDL cholesterol

Bile acids secreted into the intestines are reabsorbed and reused.
The bile-acid sequestrants bind cholesterol in the gastrointestinal tract.
The bile-acid sequestrants result in an increase in the number of LDL receptors on the
liver surface

The normal bile acids are reabsorbed from the intestines and reused by the liver. The
bile-acid sequestrants bind cholesterol in the gastrointestinal tract and prevent the
resorption of the bile from the small intestine. This insoluble bile, bound to cholesterol is
excreted in the feces.Insoluble bile cannot return to the liver, which causes the liver to

, compensate for the loss of cholesterol by increasing the number of LDL receptors on its
surface.

Bile is excreted via the gastrointestinal tract not kidney. Bile-acid sequestrants usually
lower LDL cholesterol by 10%-20%, not increase. - answer Which statement(s)
describe(s) the pharmacodynamics of bile-acid sequestrants?


The bile-acid sequestrants excrete bile in the urine.
Bile acids secreted into the intestines are reabsorbed and reused.
The bile-acid sequestrants bind cholesterol in the gastrointestinal tract.
The bile-acids sequestrants usually raise LDL cholesterol by 10%-20%.
The bile-acid sequestrants result in an increase in the number of LDL receptors on the
liver surface

The main response to bile-acid sequestrants is a reduction in LDL (low density
lipoproteins).

The mechanism of action is binding of bile acids to cholesterol in the intestine creating
insoluble cholesterol excreted through the feces.

The HDL (high density lipoproteins) does not decline in response to bile-acid
sequestrants. VLDL (very low density lipoproteins) may increase in some patients who
have high VLDL levels before with bile-acid sequestrants and are therefore not the drug
of choice. The therapeutic response to bile-acid sequestrants begins in the first week of
therapy and becomes maximal (about a 20% drop) within about a month. - answer
Which statement best describes the response to bile-acid sequestrants?

The HDL (high density lipoproteins) declines 10% in the first week of treatment.
In patients with high VLDL (very low density lipoproteins), bile-acid sequestrants are a
good first drug to consider.
The main response to bile-acid sequestrants is a reduction in LDL (low density
lipoproteins).
The therapeutic response to bile-acid sequestrants begins in the first month of therapy
and becomes maximal (about a 35% drop) in about three months.

Bile-acid sequestrants are biologically inert

Bile-acid sequestrants do not initiate a response or interact when introduced to
biological tissue.

Bile-acid sequestrants are not attacked by digestive enzymes because they are
biologically inert. Bile-acid sequestrants are insoluble; therefore, they pass directly in
the feces without retention in the intestines. Bile-acid sequestrants have no known
effect on the urinary tract. - answer Which statement describes the properties of bile-
acid sequestrants?

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