Diabetes definition
Chronic multisystem disease related to
- Abnormal insulin production
- Impaired insulin utilization
- Or both
Long term effects of diabetes
Diabetes is the leading cause of:
- Adult blindness
- End-stage renal disease
- Nontraumatic lower limb amputations
Major...
✓ - Formerly known as "juvenile onset" or "insulin dependent" diabetes
- Most often occurs in people under 30 years of age
- Peak onset between ages 11 and 13
- 5-10% of all diabetics
- Now occurring in younger children
Etiology and Pathophysiology of type 1 diabetes
✓ - End result of long-standing process
- Immune- mediated disease
- Body's own T cells attack & destroy pancreatic beta (β)- cells, which are
the source of insulin.
- Auto antibodies to the islet cells cause a reduction of 80% to 90% of normal
b cell function before hyperglycemia manifestations occur
Causes:
- Genetic predisposition
- Related to human leukocyte antigens (HLAs)
- Exposure to a virus
- Idiopathic diabetes - not related to autoimmunity but strongly inherited
Master01 | September, 2024/2025 | Latest update
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