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NUR909 Module 8 (DM) Exam With Questions And Accurate Answers
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NUR909 Module 8 (DM) Exam With Questions AndAccurate Answers
True or false: Sulfonylureas, since their introduction in the 1950s have been a main-stay
of pharmacotherapy in the management of Type II diabetes
True
Each compound contains a sulfonylurea backbone with attachment groups that
determine the drug's characteristics such as what?
Affinity for the receptor (potency)
What do sulfonylurea drugs help the body make more of?
Help the body make more INSULIN
Are sulfonylurea drugs effective in conditions in which the pancreas in not producing
insulin at all?
No!
-The pancreas has to be making some insulin
-This would include patients with a diagnosis of Type I Diabetes OR a Type II diabetic
who no longer produces insulin
How many generations of sulfonylureas are there?
3
The first generation of sulfonylurea drugs include? (3)
1. Orinase (tolbutamide)
2. Tolinase (tolazamide)
3. Diabinese (chloropropamide)
True or false: First generation sulfonylurea drugs are extremely effective, but they have
major drawbacks
True
, What is the major drawback of first generation sulfonylureas?
They are highly protein-bound
Sulfonylureas are highly-protein bound. These drugs, when co-administered with other
highly protein drugs would dislodge each other creating more "free drug" which
resulted in increased side effects such as _
Hypoglycemia
What else are first generation sulfonylurea drugs associated with?
An increased risk of cardiovascular disease
-Although recent studies have failed to prove a causal relationship
Sulfonylurea drugs have a dosing requirement of every __-__ hours
8-12 hours
True or false: With the first generation sulfonylureas, Diabinese was removed from the
market after the introduction of the second generation sulfonylureas. Generic versions
of orinase & tolinase are still available, but the brand name versions are no longer
produced
True
The second generation of sulfonylurea drugs include? (5)
1. Micronase
2. Glynase
3. DiaNeta
(glyburide)
4. Diamicron
(glicazide)
5. Glucotrol
(glipizide)
What is the only third generation sulfonylurea drug?
Amaryl
(glimempiride)
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