NROB60 FINAL NOTES Exam Questions With 100% Verified Answers
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Course
NROb60
Institution
NROb60
NROB60 FINAL NOTES Exam Questions
With 100% Verified Answers
Properties of the action potential - answerrising phase
overshoot
falling phase
undershoot
What happens when the current reaches threshold? - answergenerate APs at a low rate
What happens when current increase? - answerrate of AP g...
they react to changes in polarization of the membrane
- depolarization twists the S4 and this change in the molecule causes the gate to open
What makes the channel more permeable to Na+ ? - answer✔selectivity filter
selectivity filter - answer✔for Na channel:
- partially hydrated Na+ can fit through the pore but the partially hydrated K+ ion cannot since it
is TOO BIG
Functional properties of Na+ Channel - answer✔- threshold open up the sodium channel and
sodium can rush in
(open almost immediately)
- stays open for about 1msec then inactivates (Mg 2+ blocks it ) --> after Na+ rushes in
(this rapid opening of channels in response to depolarization explains the rising phase)
- cannot open again until voltage reduces to below threshold
- another AP cannot be generated until the channels are activated
Tetrodotoxin - answer✔could selectively block Na channel
clogs the Na permeable pore by binding tightly to a specific site on the OUTSIDE OF THE
CHANNEL
concentrated in clams, mussels, and other shellfish that feed on these organisms
marine protozoa
Batrachotoxin - answer✔- causes the channels to open at more negative potentials and to stay
open much longer than usual
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