Regis College - PSYCH 643 Week 3 4 6 8 10
13 100% VERIFIED ANSWERS 2023/2024
What are the 4 dopaminergic pathways of the brain? - ---ASNWERS---Nigrostriatal
pathway
Mesolimbic Pathway
Mesocortical Pathway
Tuberoinfundibular Pathway
Tuberoinfundibular Pathway:
Roles?
How are they implicated in the pathophysiology schizophrenia?
,What role do they have in regards to adverse effects of medications? - ---
ASNWERS---Tuberoinfundibular Pathway: regulation of prolactin release;
dopamine blockade causes an increase in prolactin levels, which results in
galactorrhea, amenorrhea, and low libido. Serotonin blockade increases
dopamine release, less risk of hyperprolactinemia.
Mesocortical Pathway:
Roles?
How are they implicated in the pathophysiology schizophrenia?
What role do they have in regards to adverse effects of medications? - ---
ASNWERS---Mesocortical Pathway: dopamine deficits results in negative Sx and
cognitive Sx; dopamine blockade can worsen negative and cognitive Sx; serotonin
blockade increases dopamine release and improves negative Sx
Mesolimbic Pathway:
Roles?
How are they implicated in the pathophysiology schizophrenia?
What role do they have in regards to adverse effects of medications? - ---
ASNWERS---Mesolimbic Pathway: dopamine overactivity results in positive Sx;
dopamine blockade improves positive Sx; serotonin blockade is not strong enough
to cause dopamine release
, Nigrostriatal pathway
Roles?
How are they implicated in the pathophysiology schizophrenia?
What role do they have in regards to adverse effects of medications? - ---
ASNWERS---Nigrostriatal pathway: normal role is control of motor movements;
the dopamine blockage results in certain extrapyramidal Sx; serotonin blockage
increases DA release, which lessens extrapyramidal Sx
What is their mechanism of action of 1st Generation (Typical) Antipsychotics? - ---
ASNWERS---Block dopamine receptors in mesolimbic, nigrostriatal, and
tuberoinfundibular dopamine tracts (these DON'T work on the mesocortical tract,
which is why they don't alleviate negative symptoms).
They also may block alpha 1 receptors (can cause orthostatic hypotension),
muscarinic (M1) receptors (responsible for anticholinergic effects), and histamine
(H1) receptors (causes weight gain).
1st gen APs - What symptoms of schizophrenia do they alleviate? - ---ASNWERS---
Positive
Name 2 high-potency 1st gen AP drugs - ---ASNWERS---High potency:
Fluphenazine (Prolixin) & Haloperidol (Haldol)
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Nurseking. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $15.49. You're not tied to anything after your purchase.
