,ThisEpageEisEintentionallyEleftEblank
,STUDENT COMPANION TO ACCOMPANY E E E
FUNDAMENTALS OF E
BIOCHEMISTRY
LIFE AT THE MOLECULAR LEVEL
E E E E
Fourth Edition E
Akif Uzman
E
University of Houston E E
Jerry Johnson
E
University of Houston E E
Joseph Eichberg E
University of Houston E E
William Widger E
University of Houston E E
Donald Voet E
University of Pennsylvania
E E
Judith G. Voet E E
Swarthmore College E
Charlotte W. Pratt E E
Seattle, Washington E
JOHNEWILEYE&ESONS,EINC
, CoverEDesignerEMadelynELesureECo
verEIllustrationENormEChristiansenEC
overEPhotos
(VitruvianEMan):E©EOdysseus/AlamyEandE©EDennisEHallinan/Alamy
MolecularEstructuresEclockwiseEfromEtop:EbasedEonEX-
rayEstructuresEthatEwereErespectivelyEdeterminedEbyERichardEDickersonEandEHoraceEDrew,ECaltech;EG
erardEBunick,EUniversityEofETennessee;EThomasESteitz,EYaleEUniversity;EAlfonsoEMondragón,ENorthw
esternEUniversity;EVenkiERamakrishnan,EMRCELaboratoryEofEMolecularEBiology,ECambridge,EU.K.;E
AndrewELeslieEandEJohnEWalker,EMRCELaboratoryEofEMolecularEBiology,ECambridge,EU.K.
FoundedEinE1807,EJohnEWileyE&ESons,EInc.EhasEbeenEaEvaluedEsourceEofEknowledgeEandEunderstandingE
forEmoreEthanE200Eyears,EhelpingEpeopleEaroundEtheEworldEmeetEtheirEneedsEandEfulfillEtheirEaspirations.
EOurEcompanyEisEbuiltEonEaEfoundationEofEprinciplesEthatEincludeEresponsibilityEtoEtheEcommunitiesEweE
serveEandEwhereEweEliveEandEwork.EInE2008,EweElaunchedEaECorporateECitizenshipEInitiative,EaEglobalEef
fortEtoEaddressEtheEenvironmental,Esocial,Eeconomic,EandEethicalEchallengesEweEfaceEinEourEbusiness.EA
mongEtheEissuesEweEareEaddressingEareEcarbonEimpact,EpaperEspecificationsEandEprocurement,EethicalEco
nductEwithinEourEbusinessEandEamongEourEvendors,EandEcommunityEandEcharitableEsupport.EForEmoreEin
formation,EpleaseEvisitEourEwebsite:Ewww.wiley.com/go/citizenship.
CopyrightE©E2012 JohnEWileyE&ESons,EInc.
AllErightsEreserved.ENoEpartEofEthisEpublicationEmayEbeEreproduced,EstoredEinEaEretrievalEsystemEorEtran
smittedEinEanyEformEorEbyEanyEmeans,Eelectronic,Emechanical,Ephotocopying,Erecording,EscanningEorEot
herwise,EexceptEasEpermittedEunderESectionsE107EorE108EofEtheE1976EUnitedEStatesECopyrightEAct,Ewit
houtEeitherEtheEpriorEwrittenEpermissionEofEtheEPublisher,EorEauthorizationEthroughEpaymentEofEtheEappr
opriateEper-
copyEfeeEtoEtheECopyrightEClearanceECenter,EInc.,E222ERosewoodEDrive,EDanvers,EMAE01923,Ewebsite
Ewww.copyright.com.ERequestsEtoEtheEPublisherEforEpermissionEshouldEbeEaddressedEtoEtheEPermissions
EDepartment,EJohnEWileyE&ESons,EInc.E111ERiverEStreet,EHoboken,ENJE07030-5774,E(201)E748-
6011,EfaxE(201)E748-6008,EwebsiteEhttp://www.wiley.com/go/permissions.
ToEorderEbooksEorEforEcustomerEservice,EpleaseEcallE1-800-CALLEWILEYE(225-5945).
StudentECompanionE(paperback) ISBN-13E 978-1-1182-1827-3
PrintedEinEtheEUnitedEStatesEofEAmeri
caE10E 9E8E7E 6E5E4E 3E2E1