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PHCY 611 Exam 1 Smitslet Questions And Answers Latest Updated
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PHCY 611 Exam 1 Smitslet Questions And Answers Latest Updated
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PHCY 611 Exam 1 Smitslet Questions AndAnswers Latest Updated
What does the acronym 3PHARMDWISED stand for? ANS✔✔ PK/PD/PGx
How
ADRs/Allergies
Regimen
Monitoring
Duration
Warnings/precautions/contraindications
Interactions
Special Populations
Education/counseling
Determinants of health
SSRI MOA ANS✔✔ inhibit SERT to block serotonin reuptake
SNRI MOA ANS✔✔ inhibit SERT and NET to block serotonin and norepinephrine reuptake, respectively
TCA MOA ANS✔✔ same as SNRI's (inhibit reuptake of 5-HT and NE by SERT and NET)
mirtazapine MOA ANS✔✔ alpha-2 adrenergic antagonist (which increases monoamine release)
bupropion MOA ANS✔✔ not fully elucidated, but it does inhibit dopamine reuptake and weakly inhibits
NE reuptake
2024
,Common non-antidepressants that can lead to serotonin syndrome ANS✔✔ -triptan meds, linezolid,
tramadol, SAM-e, St. John's wort, dextromethorphan
For each of the following, which CYP enzyme metabolizes each drug?
a) quetiapine
b) aripiprazole
c) olanzapine/clozapine
d) brexipiprazole
e) risperidone
f) haloperidol ANS✔✔ a) CYP3A4
b) CYP3A4, CYP2D6
c) CYP1A2
d) CYP2D6, CYP3A4
e) CYP2D6
f) CYP2D6, CYP3A4
Which of the following are adverse effects associated with SSRIs and/or SNRIs (select all that apply)?
a) Discontinuation syndrome
b) GI upset
c) renal toxicity
d) potential for suicidal thoughts/behaviors ANS✔✔ a), b), and d)
Which of the following (select all that apply) are symptoms of serotonin syndrome?
2024
,a) tremor
b) hypoactivity
c) hyperreflexia
d) hypothermia ANS✔✔ a) and c)
The second generation antipsychotic agents block D-1 dopamine receptors stereoselectively as their
primary mechanism of action (T/F) ANS✔✔ F
When a parenteral preparation is used for rapid initiation of treatment, the dose should be only a
fraction of what would be given orally as parenterally administered drugs have greater bioavailability
than oral dosage forms (T/F) ANS✔✔ T
Effects of 5HT1A *agonism* ANS✔✔ antidepressant, anxiolytic effects; reduces EPS
Effects of 5HT2A *agonism* ANS✔✔ worsened anxiety, insomnia, sexual dysfunction; side effects tend
to wane after 1-2 weeks
Effects of 5HT2C *agonism* ANS✔✔ worsened anxiety, insomnia, sexual dysfunction, satiety; these
effects wane after 1-2 wks of taking an antidepressant
Effects of 5HT3 *agonism* ANS✔✔ GI upset, diarrhea
Organize the SSRI's into the following categories: short, medium, long half-life ANS✔✔ short:
paroxetine, fluvoxamine
medium: sertraline, citalopram, escitalopram
long: fluoxetine
2024
, Which SSRI's are significant CYP inhibitors? Which CYP enzymes do they inhibit? ANS✔✔ fluoxetine
(CYP2D6; CYP3A4 to lesser extent)
paroxetine (CYP2D6)
fluvoxamine (CYP1A2; CYO3A4 to lesser extent)
How does venlafaxine's activity change with dose? ANS✔✔ At doses < 150 mg, only acts as SSRI but at
higher doses acts as SNRI
How does the ratio of 5HT:NE reuptake inhibition vary across SNRI's? ANS✔✔ venlafaxine is 30:1
desvenlafaxine is 10:1
duloxetine is 10:1
milnacipran is 1:1
levomilnacipran is 1:2
What is one unique adverse effect of bupropion? What risk factors can increase the likelihood of this
effect? ANS✔✔ lowers seizure threshold; eating disorders (due to electrolyte imbalance), immediate
release formulation, overdose, alcohol and other drugs that can lower seizure threshold
MOA of dextromethorphan in Auvelity ANS✔✔ NMDA receptor antagonist and NE/5-HT reuptake
inhibitor
Acronym for antidepressant withdrawal symptoms? ANS✔✔ FINISH:
Flulike symptoms
INsomnia
Imbalance
Sensory disturbance
Hyperarousal
2024
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