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NR565 MIDTERM, WEEK 4 QUESTIONS AND ANSWERS
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NR565 MIDTERM, WEEK 4 QUESTIONS AND ANSWERS
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NR565 MIDTERM, WEEK 4 QUESTIONS ANDANSWERS
what makes clopidogrel unique among other P2Y12 inhibitors? - Answers-relies on
cytochrome P450 enzyme to convert into active metabolite (CYP2C19) thus requiring
this gene to be present to be an effective drug in clot formation
Alternatives to clopidogrel - Answers-Brilinta (ticagrelor) or Effient (Prasugrel) because
they are not dependent on CYP2C19 genotype
Dose of propranolol in migraine reduction - Answers-20-80mg 3-4X daily
increases levels of serotonin, prevents beta receptor vasodilation
allow 4-6 weeks to trial treatment
First consideration in selecting most appropriate beta blocker? - Answers-Cardio
selectivity
Pregnancy Categories B vs D with beta blockers - Answers-Atenolol - D
betaxolol, acebutolol, metoprolol, nadolol, nebivolol, tiolol, propranolol - C
Where are beta 2 receptors located and what do they do? - Answers-smooth muscle of
eye, arterioles, venules, bronchioles, liver, pancreas, GI, GU
Stimulate adneylyl cyclase, increase cAMP, activate cardiac G1
Drug of choice for HTN with concomitant BPH - Answers-Alpha 1 adrenergic antagonist
Beta blockers that require dosage adjustment in patients with renal impairment -
Answers-acebutolol, atenolol, nadolol, and nebivolol
Dosing schedule of donepizil - Answers-5mg nightly at bedtime, increase at 4-6 week
intervals, max dose is 10 mg daily.
Elicits parasympathetic response - Answers-Acetylcholine, ACh
Sympathetic nervous system responses elicited by: - Answers-Epi, Norepi, Dopa
First line treatments for HTN - Answers-CCB, ACEI, ARB, or thiazide
consider comorbidities
Patients with HTN and comorbidities of essential tremor, migraine, arryhthmia, CAD,
symptomatic HF with reduced EF can be treated with? - Answers-beta blocker
2 drugs that require tapering when discontinuing in relation to HTN tx - Answers-beta
blockers and clonidine
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