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Pharmacology Module 3 Test With Complete Solutions
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Pharmacology Module 3 Test With Complete Solutions
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Pharmacology Module 3 Test WithComplete Solutions
Why is it important that carbidopa does not cross the BBB? Answer:
carbidopa would block the aromatic L-amino acid decarboxylase in the brain
Neurotransmitters are transported into vesicles (through VMAT) using:
Answer: Proton (H+) anti-porter
Neurotransmitters are transported into presynaptic neuronal terminals (NET
or DAT) using: Answer: sodium (Na+) symporter
Why does protein consumption interfere with the action of L-DOPA
(levodopa)? Answer: transporters for amino acids at the blood brain
barrier will become saturated
A 78-year-old male has been treated for Parkinson's disease with
L-DOPA/carbidopa for a period of 7 years. His symptoms are increasingly
difficult to manage, and the worsening tremor is of particular concern. The
family physician decides to initiate benztropine therapy. At the receptor
level, benztropine acts as a: Answer: muscarinic antagonist
Dopamine binding to the D2 receptor leads to: Answer: Activation of an
inhibitory G protein coupled receptor (Gαi)
Which dopaminergic neuronal pathway is dysregulated in Parkinson's
disease? Answer: Nigrostriatial
, Dopamine binding to the D1 receptor leads to: Answer: activation of a
stimulatory G protein coupled receptor (Gαs)
Clinical symptoms of Parkinson's disease including akinesia (absence of
movement) and bradykinesia (slowness of movement) are due to: Answer:
reduced dopamine leading to activation of the indirect pathway
A major distinction between dopaminergic and noradrenergic synapses is
that dopaminergic synapses are devoid of: Answer: dopamine beta
hydroxylase activity
A 60-year-old male presents to his family doctor with symptoms of rigor,
tremor, and akinesia. Based on a diagnosis of Parkinson's disease, the
patient is started on monotherapy with pramipexole. The primary action of
pramipexole in a dopaminergic synapse, as shown in the figure, is: Answer:
agonist at receptors at site D
Dopamine D1 and D2 receptors are both located in the _________, but only
_____ receptors are located in the cortex. Answer: striatum; D1
The _________ circuit organization is one in which neurons organizing in one
nucleus inervate many target cells. These systems typically exert
modulatory influence through G protein coupled receptors and have highly
branched axons enableling snaptic connections with large numbers of target
neurons. Answer: single source divergent
Fast inhibitory post-synaptic currents are driven by activation of which
receptor? Answer: GABA-A
Inhibitory G proteins (Gαi) bound by an agonist can cause _____ from a
neuron. Answer: Potassium (K+) efflux
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