Test Bank For Pharmacotherapeutics for Advanced Practice- A Practical Approach 5th Edition Arcangelo LATEST 2024|COMPLETE GUIDE A+.Test Bank For Pharmacotherapeutics for Advanced Practice- A Practical Approach 5th Edition Arcangelo LATEST 2024|COMPLETE GUIDE A+.Test Bank For Pharmacotherapeutic...
A. Distribution of drugs to target tissue may be affected i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
B. The solubility of the drug will not match the site of absorption
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
C. There will be less free drug available to generate an effect i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
D. Drugs bound to albumin are readily excreted by the kidney i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
ANS: i | i . l A PTS: i | i . l 1
2. Drugs that have a significant first-pass effect:
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
A. Must be given by the enteral (oral) route only i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
B. Bypass the hepatic circulation i|i.l i|i.l i|i.l
C. Are rapidly metabolized by the liver and may have little if any desired action
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
D. Are converted by the liver to more active and fat-soluble forms
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
ANS: i | i . l C PTS: i | i . l 1
3. The route of excretion of a volatile drug will likely be:
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
A. The kidneys i|i.l
B. The lungs i|i.l
C. The bile and feces i|i.l i|i.l i|i.l
D. The skin i|i.l
ANS: i | i . l B PTS: i | i . l 1
4. Medroxyprogesterone (Depo Provera) is prescribed IM to create a storage reservoir of i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
A. Assure that the drug will reach its intended target tissue i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
B. Are the reason for giving loading doses i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
C. Increase the length of time a drug is available and active i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
D. Are most common in collagen tissues i|i.l i|i.l i|i.l i|i.l i|i.l
ANS: i | i . l C PTS: i | i . l 1
5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug's:
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
A. Propensity to go to the target receptor i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
B. Biological half-life i|i.l
C. Pharmacodynamics
D. Safety and side effects i|i.l i|i.l i|i.l
ANS: i | i . l B PTS: i | i . l 1
6. Azithromycin dosing requires the first day's dose be twice those of the other 4 days i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
of theprescription. This is considered a loading dose. A loading dose:
i|i.l i|i.l i|.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
A. Rapidly achieves drug levels in the therapeutic range i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
B. Requires four to five half-lives to attain i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
C. Is influenced by renal function i|i.l i|i.l i|i.l i|i.l
, lOMoAR cPSD| 32744169
D. Is directly related to the drug circulating to the target tissues
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
ANS: i | i . l A PTS: i|i.l i|i.l i | i . l 1
7. The point in time on the drug concentration curve that indicates the first sign of a
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
therapeuticeffect is the:
i|i.l i|.l i|i.l i|i.l
A. Minimum adverse effect level i|i.l i|i.l i|i.l
B. Peak of action i|i.l i|i.l
C. Onset of action i|i.l i|i.l
D. Therapeutic range i|i.l
ANS: i | i . l C PTS: i | i . l 1
8. Phenytoin requires a trough level be drawn. Peak and trough levels are done:
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
A. When the drug has a wide therapeutic range i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
B. When the drug will be administered for a short time only i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
C. When there is a high correlation between the dose and saturation of receptor sites
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
D. To determine if a drug is in the therapeutic range
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
ANS: i | i . l D PTS: i | i . l 1
9. A laboratory result indicates the peak level for a drug is above the minimum
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
toxicconcentration. This means that the:
i|i.l i|.l i|i.l i|i.l i|i.l i|i.l
A. Concentration will produce therapeutic effects i|i.l i|i.l i|i.l i|i.l
B. Concentration will produce an adverse response i|i.l i|i.l i|i.l i|i.l i|i.l
C. Time between doses must be shortened i|i.l i|i.l i|i.l i|i.l i|i.l
D. Duration of action of the drug is too long i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
ANS: i | i . l B PTS: i | i . l 1
10. Drugs that are receptor agonists may demonstrate what property?
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
A. Irreversible binding to the drug receptor site i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
B. Up-regulation with chronic use i|i.l i|i.l i|i.l
C. Desensitization or down-regulation with continuous use i|i.l i|i.l i|i.l i|i.l i|i.l
D. Inverse relationship between drug concentration and drug action i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
ANS: i | i . l C PTS: i | i . l 1
11. Drugs that are receptor antagonists, such as beta blockers, may cause:
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
A. Down-regulation of the drug receptor i|i.l i|i.l i|i.l i|i.l
B. An exaggerated response if abruptly discontinued
i|i.l i|i.l i|i.l i|i.l i|i.l
C. Partial blockade of the effects of agonist drugs i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
D. An exaggerated response to competitive drug agonists
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
ANS: i | i . l B PTS: i | i . l 1
12. Factors that affect gastric drug absorption include:
i|i.l i|i.l i|i.l i|i.l i|i.l i|i.l
A. Liver enzyme activity i|i.l i|i.l
B. Protein-binding properties of the drug molecule i|i.l i|i.l i|i.l i|i.l i|i.l
C. Lipid solubility of the drug i|i.l i|i.l i|i.l i|i.l
D. Ability to chew and swallow i|i.l i|i.l i|i.l i|i.l
ANS: i | i . l C PTS: i | i . l 1
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