reaction, Mediated by IgE, Inflammation due to mast cell degranulation
/ / / / / / / / / /
Local symptoms:
/ /
-itching
-rash
Systemic symptoms: / /
-wheezing
Most dangerous = anaphylactic reaction
/ / / /
systemic response of hypotension, severe bronchoconstriction
/ / / / /
Main treatment: epinephrine reverses the effects
/ / / / /
Q 2:/
Hypersensitivity: Type 2 / / /////
...ANSWER... /
,Page /2 /of /34
Type 2: Cytotoxic reaction; tissue specific (ex: thyroid tissue)
/ / / / / / / /
Macrophages are the primary effectors cells involved
/ / / / / /
Can cause tissue damage or alter function
/ / / / / /
Grave's
disease
/
(hyperthyroidism) -
/ /
example of altering thyroid function, but does not destroy thyroid tissue
/ / / / / / / / / / /
Incompatible
blood
/
type-
/
example
/
of
/
cell/tissue
/
damage
/
that
/
occurs;
/
severe
/
transfusion
/
reaction
/
occurs
/
and
/
the transfused erythrocytes are destroyed by agglutination or complement-
/ / / / / / / / /
mediated lysis. /
,Page /3 /of /34
Q 3:/
Type 1 Hypersensitivity VS. Type 2 Hypersensitivity
/ / / / / / /////
...ANSWER... /
Type 1 Hypersensitivity
/ /
Organ Specific /
Antibody binds to the antigen on the cell surface
/ / / / / / / /
Type 2 Hypersensitivity
/ /
Not Organ Specific
/ /
Antibody
binds
/
to
/
the
/
soluble
/
antigen
/
outside
/
the
/
cell
/
surface
/
that
/
was
/
released
/
into
/
the blood or body fluids, and the complex is then deposited in the tissues
/ / / / / / / / / / / / / /
Q 4:/
, Page /4 /of /34
Hypersensitivity: Type 3 - Examples / / / / ////
/ ...ANSWER... /
Rheumatoid arthritis: Antigen/antibodies are deposited in the joints
/ / / / / / /
Systemic
Lupus
/
Erythematosus
/
(SLE)- very closely related to autoimmunity- antigen/antibodies deposit in
/ / / / / / / / /
organs that cause tissue damage
/ / / / /
Q 5: /
Hypersensitivity: Type 4 / / /////
...ANSWER... /
Delayed response /
Does not involve antigen/antibody complexes like Types 1, 2 and 3
/ / / / / / / / / /
Is T-cell mediated
/ /
Q 6: /
Differentiating Between the Rash of a Type 1 vs. Type 4 Reaction:
/ / / / / / / / / / / /////
...ANSWER... /
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