NSG 552 PSYCHOPHARMACOLOGY EXAM 1,2 & 3 BUNDLE LATEST ACTUAL EXAM QUESTIONS AND CORRECT DETAILED ANSWERS
Psychopharmacology Test bank by R.H Ettinger complete Guide for for exam Possible Questions
All for this textbook (3)
Written for
NSG 552 PSYCHOPHARMACOLOGY
All documents for this subject (54)
Seller
Follow
tutorsection1
Reviews received
Content preview
NSG 552 PSYCHOPHARMACOLOGY EXAM 1,2 & 3 BUNDLE
LATEST ACTUAL EXAM QUESTIONS AND CORRECT DETAILED
ANSWERS
Pharmacokinetics - ANSWER: Studies how the body acts on the drug
Pharmacodynamics - ANSWER: Studies how the drug acts on the body
First-generation antipsychotic - ANSWER: - first developed in the 1950s, first
available treatment for psychosis
- aka typical antipsychotics
- increased risk for EPS, Tardive dyskinesia
- d2 blocker
- Currently 11 FDA-approved and commerically available FGAs
- Most common differences between individual FGAs are their potency and side
effects
- examples include Thorazine (chlorpromazine), Haldol (haloperidol), Prolixin
(fluphenazine), perphenazine (Trilafon
Second-generation antipsychotic - ANSWER: - examples include Abilify
(aripiprazole), Seroquel (quetiapine), Zyprexa (olanzapine), Risperdal (risperidone),
Clozaril (clozapine)
- lower risk of EPS symptoms compared to 1st gen
- higher risk of metabolic side effects
- serotonin-dopamine receptor antagonists
- AKA atypical antipsychotics
EPS - ANSWER: Involuntary movements that occur as a side effect to certina
medications. AKA drug induced movement disorder. May include tardive
dyskinesia, dystonic reactions, parkinsons-like symptoms, akathesia, NMD,
akinesia
- Can be acute or chronic
- related to suppression of D2 dopamine receptors in the nigrostriatal pathway
Tardive dyskinesia - ANSWER: - characterized by involuntary movments in the face
and body
- often induced by long-term use of anitpsychotic drugs
- can be associated with use of other medication types (antidepressants, lithium,
antihistamines)
- more common with 1st gen antipsychotics
- movements may include: writhing, mouth puckering, tongue rolling, lip smacking,
pill rolling, tongue protrusion
,Upregulation - ANSWER: Refers to the activiation of the nervous system. Is the
process by which a cell increases its response to a subtance or signal from outside
the cell to carry out a specific response
downregulation - ANSWER: Refers to state of calm/relation within nervous system.
Characterized by a decreased response by a cell to a molecule or neurotransmitter.
Receptor Profiles - ANSWER: FGA - Primarily D2 antagonism. Also antagonize M2,
H1, and a1 receptors
SGA - 5-HT2A & D2 antagonism. Rapid D2 dissociation. 5HT2A agonism. Also
antagonizes M2, H1, 5HT2C, and a1 receptors
Binding - ANSWER: When a neurotransmitter binds to a receptor on a receiving
cell, it causes ion channels to open or close.
Affinity - ANSWER: The property of a drug that describes its ability to bind to a
receptor
Constant
Unique for each drug-receptor pair as it is dependent on each of their structures
CYP450 - ANSWER: - membrane-bound hemoproteins that play a pivotal role in the
detoxification of xenobiotics, cellular metabolism, and homeostatis
-Inhibitition or induction of CYP enzymes is a major mechanism underlying drug-
drug interactions
- A CYP450 inhibitor prevents or reduces work by CYP450 enzymes = decreased
drug metabolism and increased risk for toxicity
- A CYP450 inducer increases rate of hepatic metabolism = decreased serum
concentation of other drugs metabolized by the same hepatic isoenzyme
Grapefruit juice is an inhibtior, which can increase serum levels of certain drugs
Metabolic Syndrome - ANSWER: cluster of conditions that incerase risk for T2DM
and cardiovascular disease (obesity, HTN, high triglycerides, low HDL, insulin
resistance)
-increased risk for metabolic syndrome found with some antipsychotic
medications, primarily SGA
High Potency vs Low Potency - ANSWER: High potency: higher risk for
EPS/hyperprolactinemia. Effective at lower doses. Haldol, risperdal, prolixin,
olanzapine
Low potency: more sedating with more anticholinergic symptoms. Thorazine,
seroquel, clozaril, geodon
, Neuroleptic malignant syndrome (NMS) - ANSWER: - Life threatening
- occur with use of dopamine receptor antagonists or when dopaminergic
medidcation are suddenly withdrawn
- sx usually begin within 2 wks of starting a new med or changing dose.
- Characterized by fever, AMS, muscle rigidity, autonomic dysfuncton
- Dantrolene sodium is FDA approved to treat. Muscle relaxant that reduces
hyperthermia/muscle stiffness
QTC interval - ANSWER: -measurement of the left ventricle's repolarization efficiency
on ECG.
- usually 350-450 (men), 360-460 (women)
-associated with life-threatening cardiac arrhythmias
-antipsychotic and antidepressant drugs can prolong QT intervals, some more than
others
The study of the use of psychotropic medications in the treatment of psychiatric
disorders: - ANSWER: Psychopharmacology
The study of what the body does to drugs: - ANSWER: Pharmacokinetics
The study of what drugs do to the body: - ANSWER: Pharmacodynamics
Involves the absorption, distribution, metabolism and excretion of meds: - ANSWER:
Pharmacokinetics
Increase serum levels of other drugs that are substrates of that enzyme: - ANSWER:
CYP450 inhibtor
Decrease serum levels of other drugs that are substrates of that enzyme: - ANSWER:
CYP inducer
Part of the brain that regulates powerful emotions such as fear, rage, sexual desires:
- ANSWER: amygdala
The relay station for sensory information: - ANSWER: thalamus
Essential for maintaining homeostasis, controls basic needs such as sleep-wake
cycles: - ANSWER: hypothalamus
This lobe is involved in executive functioning, high order planning, speech adn
motiviation: - ANSWER: frontal lobe
Derived from Trytophan and made in the Ralphe Nuclei: - ANSWER: serotonin
Made in the Locus Ceruleus and Involved in the noradrenergic pathway: - ANSWER:
norepinephrine
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller tutorsection1. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $17.99. You're not tied to anything after your purchase.