NU 607 Week 1 Lecture Exam Questions and Answers All Correct
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Course
NU 607
Institution
NU 607
NU 607 Week 1 Lecture Exam Questions and Answers All Correct
Why is medication formulation and bioavailabilty important? - Answer- Consider...Mr. G is on digoxin tablets and runs out of his medication but he knows his neighbor Mrs. T is on digoxin so he goes and
borrows some of hers.
However...
NU 607 Week 1 Lecture Exam Questions
and Answers All Correct
Why is medication formulation and bioavailabilty important? - Answer- Consider...Mr. G
is on digoxin tablets and runs out of his medication but he knows his neighbor Mrs. T is
on digoxin so he goes and
borrows some of hers.
However, Mrs. T's dig is capsule form.
So, Mr. G goes from have 70% bioavailability of the digoxin to 90% meaning more is
available to
reach systemic circulation and possibly cause dig toxicity
what is bioequivalent? - Answer- these concepts are important when evaluating the
characteristic of a generic and trade drug
FDA - absence of a significant difference in the rate & extent to which the active
ingredients become available at the site of drug action when administered at
same dose & conditions.
Acetaminophen and Tylenol -
both 250 mg - will have same rate & extent
Drug activity needs to similar - Answer- within a range to the innovator drug
Pharmaceutical equivalent drug contain ID amounts of active drug- the excipients -
Answer- inactive ingredients
such as buffers, fillings, colorings, and flavors may differ widely from company to
company. These can cause clinical variations in rate and breakdown of drug ->
subsequent absorption.
T/F
Generic drugs must be bioequivalent to innovator drug? - Answer- T
legally have to show drug activity within a range of 80% to 125% of innovator drug.
Name the factors that affect absorption: - Answer- administration route of the drug
food or fluids admins drug
, dosage formulation
status of absorptive surface
rate of blood flow to the SI
acidity of the stomach
status of GI motility
Name the3 routes for medications - Answer- 1 Eternal(GI)
2. Parental
3.Topical
Oral drugs must dissolve in liquid and be available in solution BC - Answer- the body
cannot absorb solids.
Factors to consider with oral medications include: - Answer- *is the drug better
absorbed with or without food
*dosage formulation
*Blood flow
*Acidity of the stomach
Gut motility
Is the drug better absorbed w/wo food? - Answer- Having food in the stomach increases
gastric blood flow and increased blood flow increases absorption of the drug,
-metals in antacids (aluminum, calcium, magnesium)and calcium in milk can interfere
with absorption of antibiotics
( especially tetracycline)
Dosage formulation -> - Answer- the higher the dose the faster the absorption.
BF a drug can be absorbed it must dissolve.
rate of dissolution determines rate of absorption- differences based on formulation of
med-is it a tablet, enteric coated, SR capsules
Blood flow -> - Answer- absorption depends on normal blood flow. Food increases
blood flow which increases absorption.
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