NU 641 GOUT Medications Test Questions and Answers Graded A+
7 views 0 purchase
Course
NU 641 GOUT Medications
Institution
NU 641 GOUT Medications
NU 641 GOUT Medications Test Questions and Answers Graded A+
What two medication are used to prevent gout? - Answer- Ucicosuric Drugs- prevtion drugs
Probenecid and Sulfinpyrazone
MOA of Probenecid and Sulfinpyrazone - Answer- Increase the rate of uric acid secretion
Both inhibit renal tubula...
NU 641 GOUT Medications
Test Questions and
Answers Graded A+
What two medication are used to prevent gout? - Answer- Ucicosuric Drugs- prevtion
drugs
Probenecid and Sulfinpyrazone
MOA of Probenecid and Sulfinpyrazone - Answer- Increase the rate of uric acid
secretion
Both inhibit renal tubular reabsorption of urate; decrease serum uric acid levels
Probenecid and Sulfinpyrazone indication - Answer- No anti-inflammatory activity and
not for acute attacks. Used for prevention
Most useful for patients with reduced urinary excretion of uric acid
What is the difference between Sulfinpyrazone and Probenecid ? - Answer-
Sulfinpyrazone
Also competitively inhibits platelet prostaglandin synthesis gives drug antithrombotic
effect (antiplatelet)
What is the only antigout medication that does not require renal dose adjustment? -
Answer- Febuxostat.
All other do require
What is the only antigout medication rated pregnancy category B? - Answer-
Probenecid
Allopurinol, colchicine and febuxostat are Pregnancy Category C
Sulfinpyrazone is Pregnancy Category D
What are two antigout medications that are sulfa-based and should be used with
caution in sulfa allergies? - Answer- Probenecid and sulfinpyrazone are sulfa-based
drugs - be careful in sulfa Allergy
What are the three antigout medications that cause GI ADRs and should be used
cautiously in patients with PUD or spastic colon? - Answer- Colchicine, probenecid, and
sulfinpyrazone.
, Colchicine causes significant diarrhea
What are two antigout medications that may cause hepatoxicity ? - Answer- Allopurinol
and colchicine may cause hepatoxicity
Clinical use of Colchicine - Answer- Acute gout attacks
Low dose: 1.2 mg at the first sign of flare, followed in 1 hour with a single dose of 0.6
mg (maximum: 1.8 mg within 1 hour).
Wait 12 hours before resuming prophylaxis dose.
Should you use high dose of Colchicine to treat acute gout? - Answer- No. Current
FDA-approved dose for gout flare is substantially lower than what has been historically
used clinically. Doses larger than the currently recommended dosage for gout flare have
not been proven to be more effective. With higher doses pt tend to develop diarrhea.
How much time is usually needed for Colchicine to start working? - Answer- Pain and
swelling usually abate in 12 hrs - gone by 24-48 hrs
Prophylaxis dosing for some who has a lot of attacks - Answer- 0.6 mg once or twice
daily; maximum: 1.2 mg/day - can give just 3-4 times a week especially for some for has
diarrhea.
Is gout a form of arthritis? What happens in gout? - Answer- Yes. It is considered a form
of arthritis.
In gout, purine metabolism is altered leading to increased uric acid
Hyperuricemia
Urate Crystals deposit in joints, tendons and surrounding tissues
Usually characterized by recurrent attacks of acute inflammatory arthritis - a red, tender,
hot, swollen joint
What is the most commonly affected joint in gout? - Answer- The metatarsal-phalangeal
joint at the base of the big toe is the most commonly affected (approximately 50% of
cases)
Symptoms of gout - Answer- Acute gout presents with acute onset of pain, erythema,
decreased range of motion and swelling of involved joint
Redness is always present in gout
What medications are used to stop pain in acute gout attack? - Answer- NSAIDs and
corticosteroids
What are the names of three medications that are considered antigout? Why are they
considered antigount? - Answer- Allopurinol (Zyloprim)
Febuxostate (Uloric)
Colchicine (Colcrys)
All these drugs decrease uric acid
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Scholarsstudyguide. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $12.99. You're not tied to anything after your purchase.
