Define dose density - correct answer. Drug dose per unit of time
Define dose intensity - correct answer. Amount of drug delivered over time
How is relative dose intensity (RDI) calculated? - correct answer. By comparing the
dose that the patient ACTUALLY received to the planned dose of the standard regimen
How do alkylating agents work? - correct answer. By causing a break in the DNA helix
strand, interfering with DNA replication and causing cell death
3 subcategories of alkylating agents: - correct answer. 1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating
agents as they work similarly)
3. Nitrosoureas
Most common subcategory of alkylating agents: - correct answer. Nitrogen mustards
Hypersensitivity can occur with late doses of: - correct answer. Carboplatin
These agents are typically categorized as highly emetogenic: - correct answer. 1.
Alkylating agents
2. Nitrosoureas
Pre-administration labs for alkylating agents and nitrosoureas: - correct answer. BUN
Creatinine
CBC w/ diff
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