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NAPLEX antibiotics Exam Questions and Answers fully solved 100%

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  • NAPLEX
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  • NAPLEX

MIC -ANSWER- lowest drug concentration that prevents visibile microbial growth in 24 hours gram (+) bacteria species -ANSWER- staph, strep, EC, clostridium, listeria which antibiotics exhibit time-dependent killing? -ANSWER- penicillins, cephalosporins how can you increase the killing of a...

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  • September 23, 2024
  • 16
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • NAPLEX
  • NAPLEX
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NAPLEX antibiotics Exam Questions and
Answers fully solved 100%


MIC -ANSWER- lowest drug concentration that prevents visibile microbial growth in 24
hours

gram (+) bacteria species -ANSWER- staph, strep, EC, clostridium, listeria

which antibiotics exhibit time-dependent killing? -ANSWER- penicillins, cephalosporins

how can you increase the killing of a time-dependent antibiotic? -ANSWER- dose more
frequently, extend the infusion time

example of concentration-dependent antibiotic? -ANSWER- aminoglycosides
(gentamicin, tobramycin, amikacin)

what are the bacteriostatic antibiotics (protein synthesis inhibitors)? -ANSWER-
macrolides
aminoglycosides
tetracyclines
clindamycin
linezolid
quinupristin, dalfopristin

what is the MOA of penicillins, cephalosporins, carbapenems, and vancomycin? -
ANSWER- cell wall inhibitors - bactericidal

what general ADRs are the black box warning for aminoglycosides? -ANSWER-
nephrotoxicity and neurotoxicity

what are the aminoglycosides? -ANSWER- tobramycin
gentamicin
amikacin

what type of nephrotoxicity do aminoglycosides cause? -ANSWER- ATN - acute tubular
necrosis

what weight do you use to dose aminoglycosides? -ANSWER- IBW (unless TBW is
less)
*use ABW if obese ( > 30% IBW)

what organisms are aminoglycosides mainly active against? -ANSWER- gram (-): GNR,
PA

,extended interval dosing of the aminoglycosides? -ANSWER- gent/tobra: 4-7 mg/kg
amikacin: 15-20 mg/kg
*draw random level within 6-16 hours after dose

adjust body weight (ABW) formula? -ANSWER- IBW + [0.4(TBW - IBW)]

desired trough (traditional dosing) for gent/tobra? peak? -ANSWER- trough: < 2 mcg/mL
peak: 5-10 mcg/mL

amoxicilin brand name -ANSWER- Amoxil

what organisms do the penicillins cover? -ANSWER- mainly gram (+), some gram (-)

which penicillin is the DOC in acute otitis media? -ANSWER- amoxicillin

which penicillin has activity against PA? -ANSWER- piperacillin

which penicillins do not require renal dosing? -ANSWER- nafcillin
oxacillin
dicloxacillin

Does Amoxil suspension need to be refrigerated? -ANSWER- no - stable for 14 days at
room temperature

how do you need to take Pen VK? -ANSWER- on an empty stomach

what IV fluid is ampicillin only compatible with? -ANSWER- NS

what are the main penicillin drug interactions? -ANSWER- probenacid, allopurinol -
increased penicillin levels
may decrease levels of oral contraceptives

what type of killing do cephalosporins exhibit? -ANSWER- time-dependent

what are the first generation cephalosporins? -ANSWER- cefazolin and cephalexin

what organisms are every cephalosporin active against? -ANSWER- strep/staph and
GNR

which cephalosporins are active against PA? -ANSWER- cefepime and ceftazidime

cefazolin brand name? -ANSWER- Kefzol

cephalexin brand name? -ANSWER- Keflex

ceftriaxone brand name and generation? -ANSWER- Rocephin - 3rd gen

, cefuroxime brand name? -ANSWER- Ceftin, Zinacef

what is the lone 4th generation cephalosporin? -ANSWER- cefepime (Maxipime) - 1-2 g
Q8-12

what generation is ceftaroline (Teflaro) in? -ANSWER- 5th

what are the main side effects of cephalosporins? -ANSWER- seizures with
accumulation
increased LFTs
GI upset, diarrhea
bone marrow suppression

which cephalosporins DO NOT require renal dose adjustments? -ANSWER- ceftriaxone
(Rocephin) - 3rd generation

what are the main drug interactions of cephalosporins? -ANSWER- probenacid,
allopurinol - increased levels of cephalosporins

may decrease effectiveness of oral contraceptives

What type of killing do carbapenems exhibit? -ANSWER- time-dependent bactericidal

generic name for Primaxin? -ANSWER- imipenem / cilastatin

what organisms do the carbapenems cover? -ANSWER- everything
*ertapenem = no EC or PA
*no MRSA

Brand name for meropenem? -ANSWER- Merrem

Brand name for ertapenem? -ANSWER- Invanz

Brand name for Doripenem? -ANSWER- Doribax

can carbapenems be used in a PCN allergy? -ANSWER- NO

carbapenem drug interactions? -ANSWER- uricosuric agents (probenacid, allopurinol)
caution with seizures

MOA of flouroquinolones -ANSWER- inhibit bacterial DNA topoisomerase IV and inhibit
DNA gyrase

what type of killing to flouroquinolones exhibit? -ANSWER- concentration-dependent
bactericidal

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