Inactivated Vaccines - ANS killed whole pathogen or specific antigens or conjugates
multiple doses + booster are often needed
Advisory Committee on Immunization Practices (ACIP) - ANS updated annually available around Feb
every year
Hepatitis B - ANS spread through bodily fluids and blood products
life long infection
,perinatal transmission is COMMON
leading cause of chronic hepatitis, cirrhosis, and hepatic cancer
What are the two inactivated vaccines for Hepatitis B? - ANS Recombivax HB or Engerix-B
3 dose series (sometimes 4 doses)
What is the minimum age required for the final dose (3 or 4th) for Hep B? - ANS 24 weeks
When should the monovalent HepB vaccine be used? - ANS doses given before 6 weeks of age
Who is recommended to get revaccination of HepB? - ANS infants born to HBsAg-positive mothers
patients who are predialysis or requiring hemodialysis
other immunocompromised persons
If you have a mother that is HBsAg positive, what should you do with the baby? - ANS hepatitis B
vaccine and HBIG within 12 hours of birth
If you have a mother that is HBsAg - , and the baby has a birth weight of > 2000 g, what should you
do? - ANS give hepatitis B vaccine within 24 hours of birth
If you have a mother that is HBsAg - , and the baby has a birth weight of < 2000 g, what should you
do? - ANS hepatitis B vaccine at 1 month of age OR at hospital discharge (whichever is first)
If you have a mother that is HBsAg unknown and the baby weight > 2000 g, what should you do? -
ANS hepatitis B vaccine within 12 hours of birth
HBIG within 7 days of birth if confirmed positive OR by 7 days of life OR at hospital discharge
(whichever first) if unknown
If you have a mother that is HBsAg unknown and the baby weight < 2000 g, what should you do? -
ANS hepatitis B vaccine within 12 hours of birth
HBIG within 12 hours of birth UNLESS mother is confirmed negative by that time
,Respiratory Syncytial Virus (RSV) - ANS affects children between 0-24 months (peak at 2-8 months)
most common cause of hospitalization for respiratory tract illness in young children
by age 3: almost all children have been infected
RSV Immunization - ANS Nirsevimab, RSV-mab (Beyfortus)
For infants born October-March, and the mother did not receive a vaccine or its unknown or the
mother received RSV < 14 days prior to delivery, what should you do? - ANS 1 dose within 1 week of
birth in hospital or outpatient setting
For infants born April-September, and the mother did not receive the RSV vaccine/status unknown
or the mother received RSV < 14 days prior to delivery, what should you do? - ANS 1 dose shortly
before the start of RSV season
When is RSV season? - ANS October-March
What is the RSV vaccine and who is it recommended to? - ANS RSVpreF vaccine: Abrysvo
pregnant 32 weeks 0 days-36 weeks 6 days, gestation from September through January
Rotavirus - ANS viral illness spread primarily through fecal-oral route
acute onset of fever and vomiting followed in 24-48 hours with watery diarrhea for 3-8 days
leading cause of severe diarrhea and dehydration in infants and children
Which Rotavirus vaccine is live attenuated with 1 strain? - ANS RV-1 Rotarix
Which Rotavirus vaccine is live attenuated with 5 strains? - ANS RV-5 RotaTeq
, What do the Rotavirus vaccines have a small risk of but CDC will monitor? - ANS intussusception
(inversion of intestine)
Which rotavirus vaccine is a 2 dose series? - ANS Rotarix - RV 1
Which rotavirus vaccine is a 3 dose series? - ANS RotaTeq RV 5
If there was any dose of RV 5 or unknown... how many doses should you give them? - ANS default to
3 doses
Clinical Pearls about Rotavirus Vaccines - ANS live ORAL vaccine with shedding in stool (deferred in
inpatient)
Who is contraindicated in receiving the rotavirus vaccines? - ANS infants with severe combined
immunodeficiency (SCID) or a h/o intussusception
Diphtheria - ANS acute illness due to a toxin produced by Corynbacterium diphtheriae
paralysis of swallowing muscles, inflammation of the heart, membrane formation may cause airway
obstruction
Tetanus (lockjaw) - ANS serious, painful muscle spasms and stiffness
"locking" of the jaw so a person cannot open his or her mouth, swallow, or breathe
caused by exotoxin: Clostridium tetani
Pertussis (Whooping Cough) - ANS caused by Bordetella pertussis
characterized by a notable "whooping" sound due to the inspiratory effort after a coughing attack
T/F: All pertussis vaccines in the US are combined with diphtheria and tetanus toxoids. - ANS True
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