Hypersensitivity: Type 1 - answer-Mediated IgE
-inflammation due to mast cell degranulation
-anaphylactic, asthma, hay fever
treatment: epinephrine
Hypersensitivity: Type 2 - answer-Cytotoxic reaction: tissue specific
-binds to the antigen ON THE CELL SURFACE
-macrophages are primary effectors cells involved
cause tissue damage or alter function
Hypersensitivity 2 - answer-Graves Disease (hyperthyroidism) -alters function not
destroy
-blood transfusions reaction- transfused erythrocytes are destroyed by agglutination or
lysis
-drug allergies
-hemolytic anemia
Hypersensitivity: type 3 - answer-Not organ specific
-antibody binds to soluble antigen OUTSIDE THE CELL SURFACE that was released
into the blood or bodily fluids, and the complex is then deposited in the tissues
Renal disease associated with autoimmunity? - answerGlomerulonephritis
Sjogren's syndrome - answerInflammation in salivary and lacrimal glands
SLE - answerAutoantibodies and auto-active t-cells against DNA and nucleoprotein
Sjögren's syndrome immune changes: - answerAutoantibodies and auto-reactive t-cells
against apoptotic cells
rheumatoid arthritis manifestations: - answerJoint inflammation, stiffness, pain, loss of
range of motion
Rheumatoid Arthritis immune changes: - answerT-cells and B cells against joint
associated antigens
MS manifestations - answerFormation of sclerotic plaque in the brain, leads to Muscle
weakness and ataxia
MS immune changes - answerT-cells against brain antigens
___ measures the average size of RBCs - answerMCV
Anemia occur by... - answer-impaired RBC production
-excessive blood loss
- increased RBC production
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