Exam (elaborations)
AMR EXAM 1 ANTIBIOTICS MOA QUESTIONS AND ANSWERS
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AMR EXAM 1 ANTIBIOTICS MOA QUESTIONS AND ANSWERS
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Name: Score:21 Multiple choice questions
Definition 1 of 21
Streptogramin A: blocks tRNA binding
Streptogramin B: blocks translocation
Sulfanilamide
Chloramphenicol
Oxazolidinones
Streptogramins
Definition 2 of 21
inhibit 50S subunit
Chloramphenicol
Tetracyclines
Aminoglycosides
Macrolides
Definition 3 of 21
Caps D-Ala-D-Ala and prevents its incorporation into peptidoglycan and subsequent
crosslinking
Metronidazole
Penicillin
Vancomycin
Bacitracin
,Definition 4 of 21
poke holes in bacterial membranes
Macrolides
Lipopeptides
Tetracyclines
Oxazolidinones
Definition 5 of 21
inhibits ADC synthase → inhibits synthesis of PABA
Abyssomicin C
Vancomycin
Cycloserine
Fosfomycin
Definition 6 of 21
inhibit DNA gyrase and DNA replication
(withdrawn form the market)
Mupirocin
Novobiocin
Vancomycin
Bacitracin
Definition 7 of 21
inhibits bacterial DHFR
Fosfomycin
Penicillin
Trimethoprim
Vancomycin
, Definition 8 of 21
Binds to 50S ribosomal subunit and inhibits the initiation complex
Macrolides
Oxazolidinones
Metronidazole
Tetracyclines
Definition 9 of 21
B-lactam antibiotics bind transpeptidases much stronger than D-Ala-D-Ala.
The binding is covalent and irreversible and results in inhibition of the enzyme, cell wall
synthesis, and consequently death by cell lysis
Methotrexate
Vancomycin
Penicillin
Trimethoprim
Definition 10 of 21
Inhibits MurA, an enzyme that catalyzes the addition of enolpyruvate to UDP-N-
acetylglucosamine
Bacitracin
Metronidazole
Vancomycin
Fosfomycin
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