I HUMAN CASE WEEK, ANALYSIS EXPERT REVIEWS ( Top lated )
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I HUMAN CASE
I HUMAN CASE WEEK, ANALYSIS EXPERT REVIEWS ( Top
lated )
Genes related to Celiac disease Ms Schilling case - CORRECT ANSWERS-HLA-DQ2
HLA-DQ8 on chromosome 6 but other factors important because 40% of population has
these variants, not a great screening test. 64 other associated genes in Celiac...
I HUMAN CASE WEEK, ANALYSIS EXPERT REVIEWS ( Top
lated 2024-2025 )
Genes related to Celiac disease Ms Schilling case - CORRECT ANSWERS-HLA-DQ2
HLA-DQ8 on chromosome 6 but other factors important because 40% of population has
these variants, not a great screening test. 64 other associated genes in Celiac. 40 of
these genes interact with each other and influence TNF and IL-15
Histology and Celiac disease Ms. Schilling case - CORRECT ANSWERS-3 coverings of
the GI tract: plicae circulares, villi, microvilli. Blunting and truncation of villi, increase in
interepithelial lymphocytes, crypt hyperplasia, lymphocyte infiltration into crypts (they
should be in lamina propira)
Absorption and digestion factors in Celiac disease Ms. Schilling - CORRECT
ANSWERS-Specific enzymes and transport proteins on the cell surface of mucosal cells
to finish digestion. Less energy coming in and being utilized than usual. Lipid absorption
will also be affected due to less cells and villi on the surface. Losing surface area,
enzymes, and transport proteins.
Normal non-inflammatory response to foods Ms. Schilling case - CORRECT
ANSWERS-M-cells sample protein digests and present antigens to immune system so
that we do not react to these antigens in order to promote tolerance.
Celiac disease immune response Ms. Schilling case - CORRECT ANSWERS-Not able
to fully break down gluten, likely due to high proline content. If perforation in gut barrier
then will cause reaction. Antigen recognizing cells HLA-DQ2 HLA-DQ8 recognize
gluten. Gluten doesn't quite fit in receptor so TTG needs to change conformation in
order to fit.
Antigen recognizing cells in Celiac disease Ms. Schilling case - CORRECT ANSWERS-
HLA-DQ2 HLA-DQ8
What causes Celiac disease? Ms. Schilling case - CORRECT ANSWERS-Stress or
infection and genetic susceptibility leads to a inflammatory milieu leading to increased
antigen sampling. Higher levels of TNF and IL-15 (can turn into natural killer cells in
high amounts). HLA positive is driving force then more non-HLA genes cause more or
less vulnerability.
Micronutrients in Celiac for Ms. Schilling - CORRECT ANSWERS-Generalized problem
with clotting, slightly low hemoglobin, protein digestion/absorption affected (low albumin
which is 60% of protein in circulation), liver function looking ok, pancreatic enzymes are
low but in normal level so not playing role in disease of the patient.
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