Comprehensive and Lecture notes including slideshow notes, in class notes, images, drug charts, etc covering topics of adrenergic agonists, asthma drugs, COPD drugs, diuretics, RAAS drugs, calcium channel blockers, cardiac drugs, and heart failure drugs for Nur 243.
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regular: slideshow notes
italics: in class notes
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Chapter 21: Peripheral Nervous System Drugs- Adrenergic Antagonist
● Objectives: Neuropharmacology medications
○ Discuss the responses that an adrenergic antagonist would be expected to cause
through activation of the adrenergic receptors
○ Describe the nursing pre administration assessment data, implementation
strategies and necessary ongoing evaluation criteria
● More selective than adrenergic agonist drugs
● Prototype
○ Adrenergic antagonist:
■ Prazosin
■ Propranolol
■ Metoprolol
● Adrenergic antagonist
○ 2 groups
■ Alpha-adrenergic blocking agents (A1 only)
● Prazosin
■ Beta-adrenergic blocking agents (B1 & B2)
● Non selective- Propranolol
● Selective- Metoprolol
○ Alpha 1 selective agents
■ Prazosin
■ Vasodilation in periphery
● Patients with HTN
● Alpha 1 adrenergic antagonist
○ Pharmacological effect
■ Block alpha 1 receptors on blood vessels and bladder/prostate resulting in
vasodilation and relaxation of prostate and bladder smooth muscle
○ Therapeutic use
■ Essential hypertension
● Many underlying etiologies
● Increases systemic vascular resistance
■ Raynaud’s disease
● Have vasospasm of vessels in periphery
○ Hands and feet
● Cold fingertips
■ BPH
, ● Benign prostatic hyperplasia
● Prazosin does not shrink the prostate
○ Smooth muscle relaxation to promote urine outflow
○ Preventing urinary retention secondary to enlarged
prostate
● Check BP before administering the drug
○ Adverse effects
■ Orthostatic hypotension
■ Reflex tachycardia
,● Adrenergic antagonists
○ Terazosin (Hytrin)
■ Alpha 1 antagonist
■ Used very often for BPH
● Peripheral adrenergic receptor and related medications
, ● Adrenergic antagonists drugs: Beta blockers
○ Beta antagonists
○ Propranolol
■ Nonselective
■ First beta blocker than came on the market
● First generation
■ Indicated for people with tachycardia
○ Metoprolol
■ Cardioselective
■ Second generation
● Beta 1 adrenergic antagonist
○ Pharmacological effects
■ Reduce HR
■ Reduce force of contraction
■ Reduce AV conduction
■ Long term use results in decrease PVR
○ Therapeutic use
■ Angina (decrease oxygen demand)
■ Hypertension
■ Decreases HR
■ Cardiac Dysrhythmias
■ Heart failure
■ Stage fright
● Decreases sympathetic response
■ Migraine
● Prevents migraine
■ PTSD
● Reduction in PTSD symptoms
○ Therapeutic application of beta blockers
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