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WGU C785 Biochemistry Unit Questions/exam with correct answers verified 100%
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WGU C785 Biochemistry Unit Questions/exam with correct answers verified 100%WGU C785 Biochemistry Unit Questions/exam with correct answers verified 100% Which level of protein structure is disrupted through the hydrolysis of peptide bonds? Quaternary Tertiary Primary Secondary - corr...

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  • September 18, 2024
  • 31
  • 2024/2025
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WGU C785 Biochemistry Unit Questions/
ng ng ng ng




exam with correct answers verified 100%
ng ng ng ng ng




Whichnglevelngofngproteinngstructurengisngdisruptedngthroughngthenghydrolysisngofngpeptidengbonds?



Quaternary



Tertiary



Primary



Secondaryng-ngcorrectnganswers-Primary



Thengprimaryngstructurengofngangproteinngisngthengsequencengofngaminongacidsngheldngtogetherngbyngpeptidengbon
ds.ngPeptidengbondsngarengformedngbyngdehydrationngreactionsngandngdisruptedngbynghydrolysis.

Angmutationnginngthengbeta-
hemoglobinnggene,ngwhichngresultsnginngthengreplacementngofngthengaminongacidngglutamatenginngpositionng6ngwi
thngthengaminongacidngvaline,ngleadsngtongthengdevelopmentngofngsicklengcellnganemia.ngThengstructuresngofnggluta
matengandngvalinengarengshownngbelow.



Ifngthengbetanghemoglobinnggenenginngangpatientngwithngsickle-
cellnganemiangwerengtongbengeditedngsongthatngthengvalinenginngpositionng6ngwasngreplacedngwithngangdifferentngami
nongacid,ngwhichngreplacementngforngvalinengwouldngbengexpectedngtonghavengthengbestngclinicalngoutcome,nginngt
heory,ngforngthengpatient?ng(Assumengthengvalinengcanngpotentiallyngbengreplacedngwithnganyngaminongacidngother
ngthanngglutamate.)ng-ngcorrectnganswers-

Thengoriginalngaminongacidnginnganghealthyngpatientngisngglutamate,ngwhichngisngnegativelyngcharged.ngThengmutat
edngaminongacidngisngvaline,ngwhichngisngnon-
polar.ngValinengisngcausingngsicklengcellnganemia.ngThengbestngaminongacidngtongreplacengvalinengsongthatngthengpati
entngisnghealthyngagainngwouldngbengthengonengmostnglikengglutamate,ngsonganyngnegativelyngchargedngaminongaci
d.

Secondary,ngtertiary,ngandngquaternarynglevelsngofngproteinngstructurengcanngallngbengimpactedngbyngexposingngang
proteinngtongwhichngtreatment?

,Changengofnganghydrophobicngaminongacidngtongangdifferentnghydrophobicngaminongacid



Additionngofngangreducingngagent



PlacementngofngthengproteinnginngangsolutionngwithnganglowngpH



Increasenginngthengconcentrationngofngthengproteinnginngsolutionng-ngcorrectnganswers-
PlacementngofngthengproteinnginngangsolutionngwithnganglowngpH



ChangesnginngpHngaffectnghydrogenngbondsngandngionicngbonds.ngHydrogenngbondsnginngthengbackbonengofngamin
ongacidsngoccurnginngsecondaryngstructure,ngandngbothnghydrogenngbondsngandngionicngbondsngoccurnginngthengsid
engchainsngofngaminongacidsnginngtertiaryngstructure.

Anngincreasenginngbeta-
pleatedngsheetngstructurenginngsomengbrainngproteinsngcanngleadngtonganngincreasenginngamyloidngdepositngformat
ion,ngcharacteristicngofngsomengneurodegenerativengdiseases.ngWhatngisngthengprimaryngbiochemicalngprocessngt
hatngfollowsngthengincreasenginngbeta-
pleatedngsheetngstructurengthatngleadsngtongthengdevelopmentngofngthengamyloidngdeposits?



Anngincreasenginngglycogenngformationnginngthengbrainngcells



Aggregationngofngthengproteinsnginngthengbrain



Secretionngofngglucagon,ngleadingngtongexcessivengketogenesis



Anngincreasenginnganaerobicngmetabolismngofngglucosenginngthengbrainng-ngcorrectnganswers-
Aggregationngofngthengproteinsnginngthengbrain



Thisngquestionngisngdescribingngchangesnginngproteinngstructure.ngAggregationngoccursngwhenngproteinsngclumpng
togethernginappropriately,ngcausingngplaquesnglikengamyloidngdepositsngtongaccumulate.

Whichnglevelngofngproteinngstructurengisngdeterminedngbyngthengsequencengofngaminongacids?



Secondaryngstructure

,Quaternaryngstructure



Tertiaryngstructure



Primaryngstructureng-ngcorrectnganswers-Primaryngstructure



Thengprimaryngstructurengofngangproteinngisngsimplyngthengsequencengofngaminongacidsngheldngtogetherngbyngpepti
dengbonds.

Whichngforcengisngmostnginfluentialnginngdeterminingngthengsecondaryngstructurengofngangprotein?



Hydrophobicngeffect



Disulfidengbonding



Hydrogenngbonding



Electrostaticnginteractionsng-ngcorrectnganswers-Hydrogenngbonding



Thengsecondaryngstructurengofngangproteinngisngbuiltngbynghydrogenngbondsngbetweenngthengcarboxylnggroupsngan
dngaminonggroupsngonngthengbackbonesngofngthengaminongacids.

Whichngaminongacidngwouldngmostnglikelyngparticipatenginnghydrogenngbonds?ng-ngcorrectnganswers-
AminongAcidngstructureng4



Thisngisngangpolar,ngunchargedngaminongacidngduengtongthengOHnggroupngonngthengsidengchain.ngPolar,ngunchargedng
aminongacidsngcontainingngoxygenngorngNHnggroupsngmakenghydrogenngbonds.

Whichngportionngofngthengaminongacidngisnginsidengthengbox?
ng



ThengboxngisngsurroundingngthengsectionngbelowngthengAlphangCarbonng-ngcorrectnganswers-SidengChain

, Thengsidengchainngisngthengvariablenggroupngofngthengaminongacid,ngalsongcalledngthengRnggroup.ngEveryngaminongaci
dnghasngthengsamengaminonggroup,ngcarboxylicngacidnggroup,ngandnganngalphangcarbon,ngbutngthengsidengchainngisng
different.

Whichngpairngofngaminongacidsngwillngmostnglikelynginteractngthroughnghydrophobicngforcesngbetweenngtheirngside
ngchains?ng-ngcorrectnganswers-Bothngofngthesengaminongacidsngarengnon-

polarngandngthereforengcannginteractngtogetherngwithnganghydrophobicnginteraction.ngPleasengnotengthatngtheng"S
"nginngthengaminongacidngonngthengrightngisngnon-
polar,ngwhilengtheng"SH"nggroupnginnganswerngchoicengDngisngpolar.ngThengSngmustnghavenganngHngtongbengpolarngandng
isngotherwisengnon-polar.

Whichngportionngofngthengaminongacidngisnginsidengthengbox?



ThengboxngisngoverngthengCarbonngatngthengCenterngofngthengchainng-ngcorrectnganswers-AlphangCarbon



Thengalphangcarbonngisngthengcentralngcarbonngonnganngaminongacidngthatngholdsngtogetherngthengothernggroupsngo
fngthengaminongacid.ngItngisngalwaysngattachedngtongthengaminonggroup,ngthengcarboxylnggroup,ngthengsidengchain,nga
ndngangsinglenghydrogen.ngItngisngpartngofngthengbackbonengofngthengaminongacidngandngisngfoundnginngeveryngaminong
acid.

Givenngthengfollowingngaminongacidngstructure,ngwhatngisngthengstrongestngintermolecularngforcengitngwouldngpart
icipatenginngtongstabilizengangproteinngstructure?



Ionicngbond



Disulfidengbond



Hydrogenngbond



Hydrophobicnginteractionng-ngcorrectnganswers-Hydrophobicnginteraction



ThengaminongacidngpicturedngonlynghasngCHnggroupsnginngitsngsidengchain,ngandngthereforengisngnon-polar.ngNon-
polarngaminongacidsngmakenghydrophobicnginteractions.

Whichngchangengwouldngmostnglikelyngresultnginngangpermanentngmodificationngofnganngexpressedngprotein'sngfun
ction?

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