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NURS 8024 (Infectious Disease) PHARMACOLOGY EXAM 3 (Antimicrobial Part 2) Study Guide.
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NURS 8024 (Infectious Disease) PHARMACOLOGY EXAM 3 (Antimicrobial Part 2) Study Guide.
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NURS 8024 (Infectious Disease)PHARMACOLOGY EXAM 3
(Antimicrobial Part 2) Study Guide.
Azole ADE
✔✔NVD, rash, QT prolongation
Hepatotoxicity
Voriconazole
✔✔Causes immediate, transient visual disturbances
Systemic infections
Fluconazole
✔✔Drug of choice in esophageal & oropharyngeal candidiasis
Single dose for vaginal candidiasis
Itraconazole
✔✔Systemic infections
Posaconazole
✔✔Broad spectrum
Serious systemic infection and prophylaxis cancer chemo
Echinocandins
✔✔Newest class of antifungals
, Caspofungin-first
Anidulafungin
Micafungin
Echinocandins MOA
✔✔Interferes with the fungal cell wall synthesis
Only IV dose
Echinocandins ADE
✔✔GI Upset
Flushing, rash, elevated LFTs
Fever, HA, hypersensitivity
Griseofulvin
✔✔Fungistatic
Systemic treatment of dermatophytosis of skin & hair
Given for 2-6 weeks and needs for replacement of infected keratin
Griseofulvin ADE
✔✔HA, confusion
GI upset
Photosensitivity
Disulfiram like reactions with alcohol
Warfarin decreases bioavailability
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