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MN553 Unit 8 with complete verified solutions

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  • MN553 Advanced Pharmacology
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  • MN553 Advanced Pharmacology

MN553 Unit 8 with complete verified solutions

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  • September 16, 2024
  • 17
  • 2024/2025
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  • MN553 Advanced Pharmacology
  • MN553 Advanced Pharmacology
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MN553 Unit 8 with complete
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Charlie is a 65-year-old male who has been diagnosed with
hypertension and benign prostatic hyperplasia. Doxazosin has been
chosen to treat his hypertension because it:
1. Increases peripheral vasoconstriction
2. Decreases detrusor muscle contractility
3. Lowers supine blood pressure more than standing pressure
4. Relaxes smooth muscle in the bladder neck - answer Relaxes
smooth muscle in the bladder neck


To reduce potential adverse effects, patients taking a peripherally
acting alpha1 antagonist should do all of the following EXCEPT:


1. Take the dose at bedtime


2. Sit up slowly and dangle their feet before standing


3. Monitor their blood pressure and skip a dose if the pressure is
less than 120/80


4. Weigh daily and report weight gain of greater than 2 pounds in
one day - answer 3. Monitor their bp and skip a dose if the pressure
is less than 120/80


Which of the following adverse effects are less likely in a beta1-
selective blocker?


1. Dysrhythmias

,2. Reducing vascular smooth muscle tone


3. Increasing aldosterone-mediated volume activity


4. Reducing aqueous humor production - answer 2. Reducing
vascular smooth muscle tone


Richard is 70 years old and has a history of cardiac dysrhythmias.
He has been prescribed nadolol. You do his annual laboratory work
and find a CrCl of 25 ml/min. What action should you take related to
his nadolol?
1. Extend the dosage interval.
2. Decrease the dose by 75%.
3. Take no action because this value is expected in the older adult.
4. Schedule a serum creatinine level to validate the CrCl value. -
answer 1. Extend the dosage interval


Beta blockers are the drugs of choice for exertional angina because
they:


1. Improve myocardial oxygen supply by vasodilating the coronary
arteries


2. Decrease myocardial oxygen demand by decreasing HR and
vascular resistance


3. Both 1 and 2


4. Neither 1 or 2 - answer 2. Decrease myocardial oxygen demand
by decreasing HR and vascular resistance

, To prevent life-threatening events from rapid withdrawal of a beta
blocker:
1. The dosage interval should be increased by 1 hour each day.
2. An alpha blocker should be added to the treatment regimen
before withdrawal.
3. The dosage should be tapered over a period of weeks.
4. The dosage should be decreased by one-half every 4 days. -
answer 4. The dosage should be decreased by one-half every 4 days


Alpha-beta blockers are especially effective to treat hypertension
for which ethnic group?
1. White
2. Asian
3. African American
4. Native American - answer 3. African American


Taking which drug with food maximizes it bioavailability?
1. Donepezil
2. Galantamine
3. Rivastigmine
4. Memantine - answer 3. Rivastigmine


Which of the following drugs should be used only when clearly
needed in pregnant and breastfeeding women?


1. Memantine


2. Pyridostigmine

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