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MCMP 422 - Exam 2 Questions And Verified Answers
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MCMP 422 - Exam 2 Questions And Verified AnswersAll hematopoietic stem cells express - Answer CD34
Immature B cells develop into B cells in the - Answer secondary lymphoid organs.
Large pre-B cells are characterized by which of the following? - Answer μ is assembled
with VpreBλ5.
The latest stages of late pro-B-cell development are recognized by the association of a
surrogate light chain with a μ chain. The surrogate light chain is composed of - Answer
VpreB and λ5
Which of the following cell-surface markers identifies hematopoietic stem cells from
among the other bone marrow cell constituents? - Answer CD34
Which of the following best describes a large pre-B cell? - Answer VDJ has undergone
successful rearrangement and μ heavy chain has been produced.
Which of the following is correct?
- The κ light-chain genes rearrange before the heavy-chain genes.
- The κ light-chain genes rearrange before the λ light-chain genes.
a. The λ light-chain genes rearrange before the heavy-chain genes.
b. The λ light-chain genes rearrange before the κ light-chain genes.
c. The μ heavy-chain genes rearrange first and then the λ light-chain genes rearrange
Answer d. The κ light-chain genes rearrange before the λ light-chain genes.
,A key advantage of having two gene loci κ and λ, for the light chain is- Answers that the
chance of a successful rearrangement of light-chain genes increases.
Large pre-B cells undergo clonal expansion prior to the rearrangement of light-chain
loci. Of the options listed below which is NOT a favorable result of clonal expansion?
- Autoreactive B cells are eliminated before the energy expenditure required to
rearrange a functional light-chain gene.
• The energy spent to generate a functional heavy chain is not wasted because an
inability to generate a functional light chain. • RAG gene expression is turned off, which
in turn sends a signal to terminate the light-chain rearrangement. • A polyclonal
population of immature B cells is generated that express the same μ chain but a unique
light chain.
About 85% of small pre-B cells will go on to mature into immature B-cells - Answer
Autoreactive B cells are deleted before the energy expenditure required to rearrange a
functional light-chain gene
There are two major types of B cells designated as B-1 and B-2. Which of the following
statements is true about B-1 cells? - Answer B-1 cells first appear in the fetus
When expression of _______ is turned off in small pre-B cells, the result is that about 50%
of light-chain genes have P nucleotides but lack N nucleotides - Answer TdT
Choose all of those that are matched correctly.
early pro-B cell: VDJ rearranged
pre-B-cell receptor: VpreBλ5/μu heavy chain
mature B cell: IgM plus IgD
small pre-B cell: VJ rearranged
- immature B cell: μ heavy chain plus λ or κ light chain on surface - Answer - pre-B-cell
receptor: VpreBλ5/μu heavy chain
- mature B cell: IgM plus IgD
- immature B cell: μ heavy chain plus λ or κ light chain on surface.
, Which one of the following is not matched with its correct counterpart?
- N nucleotides: more plentiful in rearranged heavy-chain genes than in rearranged
light-chain genes
- second checkpoint in B-cell development: assembly of a functional B-cell receptor
- receptor editing: exchange of light chain for one that is not self-reactive
- first checkpoint in B-cell development: selection by the pre-B-cell receptor
- large pre-B-cell stage: constitutive expression of RAG-1 and RAG-2 proteins. - Answer
large pre-B-cell stage: constitutive expression of RAG-1 and RAG-2 proteins.
Which of the following would occur following the generation of a functional μ chain as a
pre-B-cell receptor?
- RAG proteins are degraded.
- The chromatin structure of the heavy-chain locus is reorganized to prevent gene
rearrangement.
- Transcription of the RAG1 and RAG2 genes ceases.
- There is allelic exclusion of a second μ chain.
- All of the above would occur. - Answer All of the above would occur.
Which two gene loci are involved in the chromosomal translocation that results in
Burkitt's lymphoma? - Answer Myc and a BCR gene
Anergy is a condition of some B cells. What makes a B cell anergic and by what pathway
will it most likely take in the body? The B cell will: Answer Bind to a soluble self-antigen
in the peripheral bloodstream and migrate to lymph nodes where they are detained in
the T cell area
Negative selection of developing B cells ensures that - Answer B-cell receptors that
bind to normal constituents of the body do not emerge
Receptor editing occurs ____.
- in the bone marrow
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