CMB2004 Lecture 07 Questions and Answer | Latest Update 2024/2025
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Course
Cmb2004
Institution
Cmb2004
what does immunological tolerance create
~~> random generation of repertoire of BCR and TCR production of self
reactive specificities
types of TCR recognition due to random TCR gene rearrangement
~~> - can't recognise self-MHC (die)
- recognise self MHC and p from Ag in thymus (+ve then...
can respond to self MHC when peptides are derived from AG not present in
thymus
what happens to T cells that fail +ve selection
~~> further rearrangements of TCRalpha locus
produce different R
Autoimmune Regulator (AIRE)
~~> Txn factor
in tolerance induction
expression of tissue-specific Ag in thymus
deletes T cells recognising them
Deficiency of AIRE
~~> autoimmune syndrome
what happens to self reactive BCR
Master01 | September, 2024/2025 | Latest update
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