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Drugs and the Neuroscience of Behavior An Introduction to Psychopharmacology 2nd Edition Prus Test Bank

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Drugs and the Neuroscience of Behavior An Introduction to Psychopharmacology 2nd Edition Prus Test Bank

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  • September 14, 2024
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Drugs and the Neuroscience of Behavior An
Introduction to Psychopharmacology 2nd Edition Prus
Test Bank

What is a drug? - ANSWER: any substance that changes the function of something in
an organism.

How do drugs work? - ANSWER: They bind to a target to create a response.

Pharmacodynamics - ANSWER: what the drug does to the body

Pharmacokinetics - ANSWER: what the body does to the drug

What are the steps in Pharmacokinestics? - ANSWER: 1. Drugs have to reach site of
action.
2.Influence of "Route of Administration" on PK
3. Absorption is transferred in/out of circulatory system.

2 Fundamental Features of a Drug - ANSWER: Affinity
Efficacy

Affinity - ANSWER: Tenacity (persistency) with which the drug binds to the receptor

Efficacy - ANSWER: Ability of a drug to transduce a biological effect.

Drug classification - ANSWER: 1. Pharmacologic effects.
2. Site of Action
3. Legal Statutes
4. Action site

Agonist - ANSWER: Binds to a receptor and facilitates a response

Antagonist - ANSWER: Binds to a receptor and inhibits/ blocks the receptor
response.

Drug Targets - ANSWER: Proteins, Lipids, Nucleic Acids

Major Protein targets - ANSWER: 1. Receptor
2. Ion channels
3. Transporters
4. Enzymes

Types of Receptors - ANSWER: 1. Channel-linked receptors
2. Enzyme- linked receptors

, 3. G-protein receptors
4. Intracellular receptors

Loratadine (Claritin) - ANSWER: blocks histamine receptors (no allergies)

SSRI (Selective Serotonin Reuptake Inhibitor) - ANSWER: Prozac (fluoxetine)

Lidocaine - ANSWER: local anesthetic (blocks sodium channels)

Threshold - ANSWER: Dose producing the smallest measurable response.

ED50 - ANSWER: The dose that produces 50% of the maximal response

ED100 - ANSWER: Does that produces maximal response

Potency - ANSWER: Concentration or dose of a drug required to produce a given
response.

theraputic index - ANSWER: TD50 = median toxic dose
ED50 = median effective dose
window = between those doses

TD50/ED50= TI

Safe drugs have a wider or high window/index

Illicit drugs: Dose Problems - ANSWER: 1. Impurities (not getting pharmaceutical
grade)
2. Inconsistency (varying potencies)

Tolerance - ANSWER: the diminishing effect with regular use of the same dose of a
drug, requiring the user to take larger and larger doses before experiencing the
drug's effect.
(shifts tolerance curve= closer to toxic effect)

Selectivity - ANSWER: ability of a drug to produce a certain effect... related to
specificity of the drug binding to receptors

Specificity - ANSWER: How well a drug binds to/ responds to a receptor. (only has 1
effect)

3 Major functions of the nervous system - ANSWER: 1.Sensory input CNS
2.Information processing PNS
3. Motor Output (Enteric Nervous System) ENS

CNS (central nervous system) - ANSWER: 1. consists of the brain and spinal cord
2. Coordinates body's activities

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