Exam (elaborations)
Dosage Forms Exam 2
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Dosage Forms Exam 2 Dosage Forms Exam 2 Dosage Forms Exam 2
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Dosage Forms Exam 2Which skin layer presents the major barrier for transdermal drug delivery? - CORRECT ANSWER
stratum corneum
If a patch falls off, a new patch should be put to a different skin location to continue drug release.
Why? - CORRECT ANSWER the new patch may have altered drug delivery rate if applied to the
prior skin location
(due to compromised skin barrier)
Which of the below is NOT an advantage of transdermal drug delivery?
A) fast action
B) self administration
C) needle free, painless deliver
D) avoids harsh environment of GI tract and first pass metabolism
E) ease of cessation in case of drug overdose - CORRECT ANSWER A) fast action
A patient is prescribed NicoDerm patch therapy with 14 mg for weeks 1-6 folloed by 7 mg for weeks
7-8. Which of the below is the right advice? (select all)
A) after removal of prior patch, new one can be applied to same location
B) after removal of prior patch, new patch can be applied to a different location where no patch has
been applied
C) after removal of prior patch, new patch can be applied to a location where a patch was removed 7
days ago
D) after removal of prior patch, new patch can be applied where a patch was removed 3 days ago -
CORRECT ANSWER B) after removal of prior patch, new patch can be applied to a different location
where no patch has been applied
C) after removal of prior patch, new patch can be applied to a location where a patch was removed 7
days ago
describe advantages of transdermal drug delivery - CORRECT ANSWER -self-administration
-needle free, painless delivery
-avoids harsh environment of GI tract and first pass metabolism
,-ease of cessation in case of drug overdose
-sustained release
-large skin surface area for application
How soon can a patch be applied to a previously used skin location? - CORRECT ANSWER 7 days
later
The first generation of TDD systems takes advantage of drug's inherent ability to pass through the
stratum corneum layer. Only about a dozen small lipophilic drugs can be successfully delivered with
the first generation. Which strategies have been used to enhance TDD in the second generation of
systems?
A) chemical enhancers
B) iontophoresis
C) ultrasound
D) all of the above - CORRECT ANSWER
Name the strategies used to enhance transdermal drug delivery in the second generation of TDD
systems - CORRECT ANSWER -chemical enhancers (water, ethanol, PEG, or DMSO)
-physical enhancers such as heat, ultrasound, and iontophoresis
What drugs can be delivered by first generation TDD? - CORRECT ANSWER only about a dozen
small lipophilic drugs
Which of the below drugs may be suitable for TDD?
A) drug with aqeuous solubility of 0.01 mg/mL
B) drug with log partition coefficient of -1
C) drug with MW <= 500 Da
D) drug with daily dose of 500 mg - CORRECT ANSWER C) drug with MW <= 500 Da
name the 6 physicochemical properties of drugs suitable for TDD - CORRECT ANSWER -good
lipophilicity with log partition coefficient (1-3)
-sufficient aqueous solubility (> 0.1 mg/mL)
-MW <= 500 Da
, -therapeutic dose <= 20 mg/day
-relatively potent drug
-no skin irritation
Which of the below methods can be used to increase drug delivery rate?
A) incorporation of chemical enhancers in patch preparation
B) enlargement of patch size
C) increase drug concentration in patch
D) all of the above - CORRECT ANSWER D) all of the above
The third-generation of transdermal drug delivery systems allow efficient delivery of small chemical
and biologics drugs with no restrictions on.... - CORRECT ANSWER molecular weight, partition
coefficient, and ionization status
how does the third generation of TDD systems work - CORRECT ANSWER skin microporation with
microneedles
How do you recommend that patients safely dispose of Fentanyl patches (whether used or not)? -
CORRECT ANSWER fold the adhesive layer of the patch onto itself and then flush down the toilet
Name ways in which patches may face an unwanted increase in drug delivery rate... aka what NOT to
do when using a patch - CORRECT ANSWER -application to irritated, inflamed, or broken skin
-application to wet skin
-application to lotioned skin
-exposing the patch to prolonged heat
Which is NOT a potential advantage to formulate drugs into nanopharmaceuticals:
A) increased circulation time
B) tumor-targeted delivery
C) increased target binding affinity
D) improved therapeutic efficacy
E) reduced toxicity
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