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Exam 1 Nura 221 COX inhibitors and Opioids Bellarmine Questions & 100% Correct Answers $12.49   Add to cart

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Exam 1 Nura 221 COX inhibitors and Opioids Bellarmine Questions & 100% Correct Answers

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  • Nura 221 COX

COX ~~> cyclo-oxygenase an important enzyme in the synthesis of prostaglandin Cox is found in all tissues and helps regulate many processes COX inhibitors ~~> NSAIDs (Non-Steroidal Anti-Inflammatory Medications) and selective COX2 inhibitors COX-1 (5 things) ~~> *This is the ...

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  • September 12, 2024
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  • 2024/2025
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1 | P a g e | © copyright 2024/2025 | Grade A+




Exam 1 Nura 221 COX inhibitors and
Opioids Bellarmine Questions & 100%
Correct Answers
COX

✓ ~~> cyclo-oxygenase




an important enzyme in the synthesis of prostaglandin

Cox is found in all tissues and helps regulate many processes




COX inhibitors

✓ ~~> NSAIDs (Non-Steroidal Anti-Inflammatory Medications)

and selective COX2 inhibitors




COX-1 (5 things)

✓ ~~> *This is the protective cox and is located in all tissues




1. Protects the gastric area by reducing secretion of gastric acid




2. Increasing secretion of bicarbonate and cytoprotective mucus




Master01 | September, 2024/2025 | Latest update

, 2 | P a g e | © copyright 2024/2025 | Grade A+



3.Maintenance of sub-mucosal blood flow




4. Catalyzes synthesis of PGE2 and PGI2 which promote vasodilation and

therefore increased renal blood flow




5. Promotes synthesis of TXA2 (which stimulates platelet aggregation, which

can be a negative event) in positive way it can clot (stop bleeding) a cut




COX-2

✓ ~~> *reactive cox

This is present only at the site of tissue injury and the brain




When activated it:

Causes inflammation

Causes pain

Causes fever (increased heat at site of injury)




Two types of COX

✓ ~~> COX-1

COX-2



Master01 | September, 2024/2025 | Latest update

, 3 | P a g e | © copyright 2024/2025 | Grade A+




Examples of NSAIDs

✓ ~~> - Ibuprofen (Advil/Motrin)

- Naproxen & Naproxen Sodium (Naprosyn & Aleve)

- Aspirin

- Indomethacin (Indocin)

- Ketorolac (Toradol)




3 primary functions of NSAIDS

✓ ~~> •Suppression of inflammation

•Relief of pain (analgesic)

•Reduction of fever (anti-pyretic)




Two types of Cox inhibitors

✓ ~~> specific and non-specific




What are non-specific cox inhibitors?

✓ ~~> NSAID that blocks the action of cox1 and cox2




also called First-generation



Master01 | September, 2024/2025 | Latest update

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