Probenecid and penicillin combination exhibits this type on interaction:
a. Enzyme induction
b. Enzyme inhibition
c. Alteration in gastric emptying
d. Competition in tubular secretion - ANS d. Competition in tubular secretion
A physiological or psychological state resulting from d...
Probenecid and penicillin combination exhibits this type on interaction:
a. Enzyme induction
b. Enzyme inhibition
c. Alteration in gastric emptying
d. Competition in tubular secretion - ANS d. Competition in tubular secretion
A physiological or psychological state resulting from drug administration:
a. Drug dependence
b. Drug habituation
c. Drug addiction
d. Drug tolerance - ANS a. Drug dependence
Monoamine oxidase inhibitors (MAOIs) and foods like cheese will lead to:
a. Accumulation of catecholamines
b. Increase in blood pressure
c. Non-metabolism of tyramine
d. All of the above - ANS d. All of the above
Enzyme induction of phenobarbital with oral contraceptives can lead to:
a. Decreased phenobarbital action
b. Increased oral contraceptive action
c. Unreliable contraception
d. None of the above - ANS c. Unreliable contraception
The following type/s of incompatibility may be dispensed:
a. Unintentional incompatibility
b. Intentional incompatibility
c. Delayed chemical incompatibility but within shelf-life of product
d. Both B and C - ANS d. Both B and C
The transport of a substance from one part of the body to another by means of blood:
a. Absorption
c. Metabolism
,b. Distribution
d. Excretion - ANS b. Distribution
A drug-induced hypersensitivity reaction caused by sulfonamides:
a. Parkinson's Disease
c. Hypertension
b. Stevens-Johnson's Syndrome
d. Contact Dermatitis - ANS b. Stevens-Johnson's Syndrome
The following is/are true regarding absorption of salicylic acid:
I. Non-ionized form is more lipid-soluble and absorbable
II. Ionized form is more lipid-soluble and absorbable
III. Polar form is more readily absorbed
IV. Absorption is decreased when taken with antacid
a. I, III
c. I, IV
b. II, III
d. III, IV - ANS c. I, IV
Remedy when a liquid substance fails to homogenize in a liquid:
a. Addition of an inert agent
b. Prepare an emulsion
c. Prepare a suspension
d. Dispensing the ingredients
separately - ANS b. Prepare an emulsion
An anionic exchange resin intended to bind acids, cholesterol metabolites and co-administered
drugs:
a. Chloramphenicol
b. Cholesterol precursor
c. Tetracycline
d. Cholestyramine - ANS d. Cholestyramine
Delay in gastric emptying time for the drug to reach the duodenum will _____, thereby
prolonging the onset of time for the drug:
a. Slow the rate and extent of drug distributon
b. Slow the rate and extent of drug absorption
c. Increase the rate and extent of drug absorption
d. Increase the rate and extent of drug metabolism - ANS b. Slow the rate and extent of
drug absorption
In basic urine, acidic drugs are:
a. Non-ionized, hence reabsorbed, decrease half life
,b. More ionized, not reabsorbed, decrease half life
c. More non-ionized, not reabsorbed, increase half-life
d. Non-ionized, not reabsorbed, increased elimination rate - ANS b. More ionized, not
reabsorbed, decrease half life
Pharmacokinetically, enzyme induction will result to the following, except:
a. Peak level decreases
b. Accelerated metabolism
c. Increased overall elimination rate
d. Pharmacological responses are decreased - ANS d. Pharmacological responses are
decreased
Phenobarbital-antihistamine drug combinations will result to:
a. Phenobarbital metabolism is accelerated by antihistamine
b. Antihistamine metabolism is accelerated by phenobarbital
c. Phenobarbital peak level increases
d. Decreased phenobarbital overall elimination rate - ANS b. Antihistamine metabolism is
accelerated by phenobarbital
The unusual result of triturating camphor and menthol is:
a. Liquefaction
b. Efflorescence
c. Hygroscopicity
d. Deliquescence - ANS a. Liquefaction
The degradation reaction of aspirin involves:
a. Hydrolysis
b. Racemization
c. Oxidation
d. Photolysis - ANS a. Hydrolysis
Substances which absorb moisture from the air are called:
a. Effervescent powders
c. Anhydrous powders
b. Hygroscopic powders
d. Efflorescent powders - ANS b. Hygroscopic powders
The reaction between sodium bicarbonate and aspirin would result to:
a. Formation of precipitate
c. Hydrolytic changes
b. Evolution of gas
d. Invisible changes - ANS b. Evolution of gas
Involves the degradation of the drug or excipients through reaction with the solvents
, present in the formulations:
a. Solvolysis
b. Oxidation
c. Photolysis
d. Polymerization - ANS a. Solvolysis
Anaphylaxis is:
a. Type A ADR
c. Type E ADR
b. Type B ADR
d. Type F ADR - ANS b. Type B ADR
Acacia in the presence of bismuth salts can form a 'cake' at the bottom of the container. This
manifestation is known as:
a. Gelatinization
b. Cementation
c. Hydrolysis
d. Emulsification - ANS b. Cementation
.Sudden withdrawal of steroids can result to:
a. Anemia
b. Hypertension
c. Parkinson's Disease
d. Addison's Disease - ANS d. Addison's Disease
Oxidation:
a. Loss of electrons
c. Cause of drugs instability
b. Dehydrogenation
d. All of the above - ANS d. All of the above
The following are true regarding excretion of acidic drugs, except:
a. Exist in the ionized state in alkaline urine
b. Exist in the non-ionized form in acidic urine
c. Acidic urine increases drug action
d. None of the above - ANS d. None of the above
Precipitation can be:
a. Physical incompatibility
c. Adverse drug reaction
b. Chemical incompatibility
d. A and B - ANS d. A and B
Citric acid, atropine sulfate and ferrous sulfate are classified as:
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