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NR566 Final (Advanced Pharmacology for Care of the Family)Questions & Answers(SCORED A+) $12.49   Add to cart

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NR566 Final (Advanced Pharmacology for Care of the Family)Questions & Answers(SCORED A+)

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Anti-Androgens - ANSWER Finasteride (Propecia) Leuprolide (Eligard, Lupron, Lupron Depot) Spironolactone (Aldactone) Finasteride (Propecia, Proscar) - ANSWER blocks conversion of testosterone to dihydrotesterone Used to tx: -BPH -male pattern baldness 3 months of therapy need to see...

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  • September 10, 2024
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  • Exam (elaborations)
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  • NR566(Advanced Pharmacology
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NR566 Final (Advanced
Pharmacology for Care of the
Family)Questions &
Answers(SCORED A+)

Anti-Androgens - ANSWER Finasteride (Propecia)

Leuprolide (Eligard, Lupron, Lupron Depot)

Spironolactone (Aldactone)



Finasteride (Propecia, Proscar) - ANSWER blocks conversion of testosterone to dihydrotesterone



Used to tx:

-BPH

-male pattern baldness

3 months of therapy need to see benefits

Stopping, reverses effect w/in 12 months



Adverse side effects:

- Decreased libido

-Impotence



dutasteride (Avodart) - ANSWER 5-alpha reductase inhibitor

used to tx:

BPH

,Can stay in serum up to 6 mon after discontinuing



can be absorbed through skin

pregnant woman shouldn't handle capsules

(fetal anomaly in male fetus)



Adverse Effects

decreased libido

Impotence



Leuprolide Acetate (Lupron) - ANSWER Luteinizing hormone - releasing agonist

create reversible:

-orchiectomy state

-oophorectomy state



Used to tx:

- advanced prostatic cancer

- Management of endometriosis

- Uterine fibroids

- polycystic ovarian disease

- central precocious puberty in peds



Flutamide (Eulexin, Euflex) - ANSWER Truly non-steroidal agent

Used to tx:

-Advanced prostate cancer

-female androgen excess syndrome



Adverse Effects in males

- gynecomastia

-reversible liver toxicity

, Black Box Warning

-hepatic failure

-hepatic encephalopathy

Basline/monthly liver function test for 1st 4 months



Contraindications for Testosterone - ANSWER Male breast cancer

prostate cancer

Pregnancy (X category)

Lactation



Complications of Testosterone - ANSWER - Edema w/or w/out congestive heart failure

(use caution in pts w/ preexisting cardiac, renal, or hepatic disease)

Increased risk for

-prostatic hypertrophy

-prostatic hyperplasia

-prostatic carcinoma

Hypogonadal men might experience sleep apnea

This risk increases in men w/obesity or chronic lung disease.



Refer to endocrinologist - ANSWER stimulating growth in boys with delayed puberty

aging men to increase strength + muscle mass



Adverse Reactions Androgens - ANSWER Prolonged high dose use =

-life threatening hepatitis

-hepatic neoplasms

-Hepatocellular carcinoma



Methyltestosterone + fluoxymesterone low dose:

-cholestatic hepatitis

-Jaundice

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