Exam (elaborations)
PMCOL 371 Lecture 11- Neurotransmitter Actions Study Set Exam
- Course
- Institution
PMCOL 371 Lecture 11- Neurotransmitter Actions Study Set Exam ...
[Show more]
Content preview
PMCOL 371 Lecture 11-Neurotransmitter Actions Study
Set Exam
How is an AP initiated? - Answer when EPSP is big enough to bring cell to threshold
What are the six criteria that a substance must meet to be considered a
neurotransmitter? - Answer 1. presence and synthesis
2. release
3. identity of action
4. pharmacology
5. inactivation
6. behavioural criteria
Describe the 'presence of synthesis' criteria for being a neurotransmitter. - Answer
presynaptic neuron should contain the transmitter and be able to synthesis it
Describe the 'release' criteria for being a neurotransmitter. - Answer transmitter should
be released on stimulation of the presynaptic neuron
Describe the 'identity of action' criteria for being a neurotransmitter. - Answer
application of the transmitter to the postsynaptic cell should reproduce the effects of
normal transmission
Describe the 'pharmacology' criteria for being a neurotransmitter. - Answer action of
transmitter and effect of presynaptic nerve stimulation should be altered in the same
way by antagonists
Describe the 'inactivation' criteria for being a neurotransmitter. - Answer there should
be a mechanism of inactivation of the transmitter
Describe the 'behavioural' criteria for being a neurotransmitter. - Answer drugs that
affect the transmitter systems should have observable effects on the whole animal
Where is the neurotransmitters binding site on ionotropic receptors? - Answer binding
site is intrinsic to the ion channel protein
What are the 3 effects of neurotransmitters on ionotropic receptors? - Answer 1.
neurotransmitter interacts directly with ion channel
, 2. involved in the generation of fast EPSPs and IPSPs
3. involves increases in conductance to cations or anions
What are 5 examples of ionotropic receptors that neurotransmitters have actions on? -
Answer 1. nicotinic Ach receptor
2. GABAa receptor
3. glycine receptor
4. 5HT3 receptor
5. NMDA, AMPA, and Kainate receptors (iGluR)
Describe the neurotransmitters binding site on metabotropic receptors. - Answer -
binding site is remote
- info from the neurotransmitter binding site is transduced via G proteins and/or via
second messengers
What are the 4 effects of neurotransmitter binding to metabotropic receptors? - Answer
1. interacts indirectly with the ion channel
2. neuromodulatory effects
3. often lead to decreases in conductance of K+ or Ca2+ channels
4. pleiotropic action
What does pleiotropic action of neurotransmitters mean? - Answer pleiotropic =
producing more than one effect
- because they can activate second messengers, they can orchestrate a change in
physiological status of postganglionic neuron
- neurotransmitter can affect a variety of ion channels, ion pumps, enzymes, and gene
expression
What are 4 examples of metabotropic receptors? - Answer 1. muscarinic ACh receptor
2. alpha and beta adrenoceptors
3. metabotropic amino acid receptor
4. peptide receptors
Which neurotransmitters can act at both ionotropic and metabotropic receptors? -
Answer ACh, GABA, Glutamate, and 5HT
Which neurotransmitters act only on metabotropic receptors? - Answer peptides and
catecholamines
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Zayla. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
79373 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now