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PMCOL 200 Drugs Study Set Exam
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PMCOL 200 Drugs StudySet Exam
penicillin and cephalosporin - Answer class: cell wall inhibitor
transpeptidase inhibitor
bacteriocidal
beta lactam ring
beta-lactamases - Answer bacterial enzymes that hydrolyze the beta-lactam ring of
penicillins and cephalosporins
made by staphylococci and other gram negative bacteria
beta lactam inhibitors - Answer calvanulic acid
inhibitor of beta-lactamases
vancomycin - Answer cell wall inhibitor
inhibits peptidoglycan cross linking
NOT a beta-lactam
Sulfonamides - Answer folic acid inhibitor
competes with PABA
trimethoprim - Answer folic acid inhibitor
resembles dihydrofolic acid
chloramphenicol and macrolides - Answer protein synthesis inhibitors
bind 50S subunit and block transpeptidation
tetracylines - Answer protein synthesis inhibitor
bind 30s subunit
aminoglycosides - Answer protein synthesis inhibitor
bind 30s subunit
, 1. block initiation of the complex
2. cause misreading of code on mRNA template
3. inhibit translocation
Acyclovir - Answer antiviral
nucleoside analog - DNA chain termination
Amantadine - Answer antiviral
inhibits viral uncoating of influenza A - blocks proton transfer through M2, blocking
acidification and initiation of viral transcription
Zanamivir - Answer Antiviral. Inhibits NA in Influenza => viral aggregation; unable to exit
host cell; and reduced spread in airways.
Maraviroc - Answer CCR5 receptor antagonist (entry inhibitor)
NTRIs - Answer nucleoside reverse transcriptase inhibitor
compete with nucleoside triphosphates
non-NTRIs - Answer bind different site than NTRIs and inhibit activity of reverse
transcriptase
Raltegravir - Answer Integrase Strand Transfer Inhibitor (INST)
Protease inhibitors - Answer inhibits aspartate proteases (HIV-1 protease)
inhibits formation of mature virion
pyrimidine analogues - Answer 5-fluorouracil (5-FU)
compete for enzyme thymidylate synthase
purine analogues - Answer 6-mercaptopurine
inhibits purine nucleotides synthesis by inhibiting PRPP amidotransferase
cyclophosphamide - Answer alkylating agent
most susceptible in late G1/S
covalently links chemical groups in NA, cross-links DNA and breaks strands
cisplatin - Answer alkylating agent
platinum analog
leads to inter-strand crosslinks, leading to inhibition of DNA synthesis and function
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