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Pmcol 305 Amphetamines Exam Study Guide
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Pmcol 305 Amphetamines ExamStudy Guide
From what is amphetamine derived from - Answer Chinese medicinal herb called Ma
Huang or Ephedra Sinica
Who was the first to synthesize AMPH - Answer Lazar Edeleano made alpha
methylphenethylamine in 1887 to treat athsma
L-Amphetamine - Answer Into pageR, aises BP, Nasal passages open and headache
D-Amphetamine - Answer Same as L but added mood enhancement and enhances
energy
Methamphetamine - Answer Increased lipid solubility causes increase potency and
brain effects
Most potent amphetamine - Answer Meth
least potent amphetamine - Answer L-Amphetamine
3 Ways to make methamphetamines - Answer Nagai
synthesis-Pseudoephedrine/ephedrine+Acid and red phosphorus
Reductive Amination
Phenylacetone+Methyl amine
Leuckart Synthesis
Phenylacetone + N-methylformamide
Amphetamines are structurally close to.. - Answer Catecholamines
Why is Meth the drug of choice - Answer Extra methyl group, Slower metabolism, CNS
effects are stronger, Smokeable and cheaper
Absorption of Amphetamines - Answer (fastest onset) Smoked (70%), Injected,
snorted(80) or ingested (70-99%) (Slowest onset)
What is Ice - Answer The strongest form of methamphetamine, HCl salt, what crack is to
cocaine
Meth lasts longer/shorter than cocaine - Answer Longer
What metabolizes Meth and Amph - Answer CYP2D6
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