NUR 615 PHARM EXAM WITH 200 QUESTIONS AND VERIFIED ANSWERS (ALREADY GRADED A+) MARYVILLE UNIVERSITY- BRANDNEW!!!
4 views 0 purchase
Course
NUR 615 PHARM
Institution
NUR 615 PHARM
NUR 615 PHARM EXAM WITH 200 QUESTIONS
AND VERIFIED ANSWERS (ALREADY GRADED A+)
MARYVILLE UNIVERSITY- BRANDNEW!!!
Why does absorption occur at a slower rate for oral, IM, SQ
routes? - ANSWER-Absorption occurs at a slower rate because
the complex membrane systems of GI mucosal layers, mus...
Why does absorption occur at a slower rate for oral, IM, SQ
routes? - ANSWER-Absorption occurs at a slower rate because
the complex membrane systems of GI mucosal layers, muscle,
and skin delay drug passage.
The ability of a drug to cross a cell membrane depends on: -
ANSWER-whether the drug is water or lipid (fat) soluble. Lipid-
soluble drugs easily cross through cell membranes; water-soluble
drugs can't. Lipid-soluble drugs can also cross the blood-brain
barrier and enter the brain.
As a drug travels through the body, it comes in contact with? -
ANSWER-proteins such as the plasma protein albumin. The drug
,2|Page
can remain free or bind to the protein. The portion of a drug that's
bound to a protein is inactive and can't exert a therapeutic effect.
Only the free, or unbound, portion remains active. A drug is said
to be highly protein-bound if more than 80% of the drug is bound
to protein.
Identify drug metabolism and the role of isoenzymes in the p450
system - ANSWER-CYPs are the are the major enzymes involved
in drug metabolism accounting for about 75% of the total
metabolism.
Naturally occurring compounds may induce or inhibit CYP activity.
- ANSWER-For example, bioactive compounds found in grapefruit
juice and some other fruit juices including dihydroxy forgotten and
parasitin A have been found to inhibit CYP3a4 mediated
metabolism of certain medications leading to increased
bioavailability and the strong possibility of overdosing.
,3|Page
What does grapefruit have to do with CYP? - ANSWER-Grapefruit
is an inhibitor and will decrease the metabolism of drugs by the
cyp enzymes
When 2 drugs are both metabolized by the p450 system the drug
should be - ANSWER-administered at separate times to prevent
the metabolism of one drug resulting in toxic effects of the other
drug. (because it would have less protein to bind too, thus more
free floating drug)
What is the efficacy of a drug? - ANSWER-Efficacy is the
maximum response achievable from a drug. Effectiveness refers
to the ability of the drug to produce a beneficial effect.
, 4|Page
On the drug concentration curve what is the first sign of a
therapeutic effect? - ANSWER-The onset of action
What is the purpose of a peak and trough level? - ANSWER-To
determine if the drug is in therapeutic range.
Describe the purpose of blood brain barrier - ANSWER-The BBB
is a highly selective permeability barrier that separates the
circulating blood from the brain and extracellular fluid in the CNS.
The BBB is formed by brain endothelial cells which are connected
by tight junctions with an extremely high electrical resistivity of at
least 0.1 micron. The BBB allows the passage of water, some
gases, and lipid soluble molecules by passive diffusion as well as
the selective transport molecules such as glucose and amino
acids that are crucial to neuro function.
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller edwinnyamoita. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $19.99. You're not tied to anything after your purchase.
