Path Ch 2 Exam Questions with Definitive Solutions/ .
5 views 0 purchase
Course
Path Ch 2
Institution
Path Ch 2
Path Ch 2 Exam Questions with Definitive Solutions/ . Terms like:
On the other hand, systemic pathology examines the _____________________ - Answer: alterations and underlying mechanisms in organ specific diseases such as ischemic heart disease
Path Ch 2 Exam Questions with Definitive
Solutions/ 2024-2025.
On the other hand, systemic pathology examines the _____________________ -
Answer: alterations and underlying mechanisms in organ specific diseases such as
ischemic heart disease
The four aspects of a disease process that form the core of pathology are its
________________________________________________ - Answer: cause
(etiology), the biochemical and molecular mechanisms of its development
(pathogenesis), the structural alterations induced in the cells and organs of the
body (morphologic changes), and the functional consequences of these changes
(clinical manifestations).
Page 1 of 117
,Although there are myriads of factors that cause disease, they can all be grouped
into two classes: __________________________________ - Answer: genetic
(e.g., inherited mutations and disease-associated gene variants, or
polymorphisms) and acquired (e.g., infectious, nutritional, chemical, physical)
The idea that one etiologic agent is the cause of one disease—developed from the
study of infections and inherited disorders caused by single genes—is not
applicable to ___________________ - Answer: the majority of diseases
In fact, most of our common afflictions, such as atherosclerosis and cancer, are
multifactorial and arise from the effects of ______________________ - Answer:
various external triggers on a genetically susceptible individual.
Pathology is devoted to the study of ___________________________ changes in
cells, tissues, and organs that underlie disease. - Answer: the structural,
biochemical, and functional
By the use of molecular, microbiologic, immunologic, and morphologic
techniques, pathology attempts to explain the whys and wherefores of the
_______________________ - Answer: signs and symptoms manifested by
patients while providing a rational basis for clinical care and therapy.
jury and death. Traditionally the study of pathology is divided into
______________________ - Answer: general pathology and systemic pathology
Page 2 of 117
,General pathology is concerned with the common reactions of cells and tissues to
injurious stimuli. Such reactions are
________________________________________ - Answer: often not tissue
specific: thus acute inflammation in response to bacterial infections produces a
very similar reaction in most tissues.
____________________ refers to the sequence of cellular, biochemical, and
molecular events that follow the exposure of cells or tissues to an injurious agent.
- Answer: Pathogenesis
The study of ______________ remains one of the main domains of pathology. -
Answer: pathogenesis
Even when the initial cause is known (e.g., infection or mutation), it is
______________________ - Answer: many steps removed from the expression of
the disease.
Indeed, as we shall see throughout the book, the mutated genes underlying a
great number of diseases have been identified, but the functions of the
________________________. - Answer: encoded proteins and how mutations
induce disease—the pathogenesis—are still not fully understood
Page 3 of 117
, Morphologic changes refer to the _____________ in cells or tissues that are either
characteristic of a disease or diagnostic of an etiologic process - Answer:
structural alterations
Traditionally, the practice of diagnostic pathology has used _____________ to
determine the nature of disease and to follow its progression. - Answer:
morphology
Although morphology
remains a diagnostic cornerstone, its limitations have been
evident for many years. For example, morphologically
identical lesions may arise by distinct molecular mechanisms. Nowhere is this
more striking than in the study of
______________________ - Answer: tumors; breast cancers that are
indistinguishable morphologically may have widely different courses, therapeutic
responses, and prognosis
Molecular analysis by techniques such as next generation sequencing (Chapter 5)
has begun to reveal ____________________________________ - Answer:
genetic differences that predict the behavior of the tumors as well as their
responsiveness to different therapies
Increasingly, targeted therapies based on ________________ are being used for
the treatment of cancers. - Answer: molecular alterations
Page 4 of 117
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller docmickey. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $9.49. You're not tied to anything after your purchase.
