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BMS 2 PHCY 402 Fluoroquinolones Study Set Exam
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BMS 2 PHCY 402Fluoroquinolones Study Set
Exam
Ciprofloxacin - Answer 2nd generation; has cyclopropyl group; IV, PO, and opthalmic;
1st line Pseudo, Legionella, Mycoplasma pneumonia; Interactions increases xanthines,
decreases phenytoin, decreases thyroid, chelates cations
Ofloxacin - Answer 1st gen; racemic mixture; tabs, otic, and ophthalmic; Pseudomonas
UTI, ear, and eye infections
Levofloxacin - Answer 1st gen; the single chiral form of ofloxacin (increases potency x2
and decreases SE); IV, tab, solutions, and opthalmic; 1st line Penicillin resistant Strep.
pneumoniae
Gatifloxacin - Answer 2nd gen; OMe and cyclopropyl groups; ophthalmic; Pseudomonas
and some gm+ and anaerobe; Treats eye infections
Moxifloxacin - Answer 3rd gen; side chain increases gyrase binding and has OMe and
cyclopropyl; IV, tab, and opthalmic; Gm- and + and good anaerobe; 1st line penicillin
resistant Strep. pneumoniae and legionella pneumophila
Gemifloxacin - Answer 3rd gen; side chain increases gyrase binding and has
cyclopropyl; tab only; Gm- and + ans good anaerobe but not active against many KES;
1st line penicillin resitant strep. pneumoniae; SE skin rash mostly in women
Finafloxacin - Answer 3rd gen; cyano group increases activity against CA-MRSA; treats
otitis externa (swimmers ear which is combo of pseudomonas and staph. aureus)
Delafloxacin - Answer 3rd gen; tab and injectable salt; Treats S/SSI, staph including
MRSA and strep, e coli, Klebsiella, and Pseudomonas
Ozenoxacin - Answer "New quinolone"; impetigo, staph aureus (MRSA) and strep.;
topical treatment
Metronidazole - Answer synthetic compound; 'cidal'; 1st line for anaerobes,
bacteriodes, c.diff, c.perfringes; IV and oral; SE disulfiram like activity; Interactions
anticoagulants and disulfiram; resistance increasing non UTI bacteria
secnidazole - Answer synthetic compound; treats bacterial vaginosis (bacteroides,
gardnerella vaginalis, provotella); oral granules added to yogurt, do NOT chew; SE
nausea diarrhea headache and vaginal candidiasis; CI carcinogen possibly, preganncy,
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