BLOCK 3 PMY 302 - DRUGS to KNOW. Exam Study Guide.
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Course
PMY 302
Institution
PMY 302
BLOCK 3 PMY 302 - DRUGS to KNOW.
Exam Study Guide.
Somatropin Drug Class - answerSynthetic recombinant human growth hormone
Somatropin MOA - answerIdentical in action and abilities like endogenous secreted GH
(stimulating proliferation of bone growth plates and increased linear bone growth, pro...
BLOCK 3 PMY 302 - DRUGS to KNOW.
Exam Study Guide.
Somatropin Drug Class - answer✔✔Synthetic recombinant human growth hormone
Somatropin MOA - answer✔✔Identical in action and abilities like endogenous secreted GH
(stimulating proliferation of bone growth plates and increased linear bone growth, promotion of
protein synthesis throughout the body)
Somatropin/Somatrem dosing - answer✔✔Daily dosing dependent and adjusted to individual
clinical response and IGF-1 levels
Somatropin/Somatrem pharmacokinetics - answer✔✔Following SC injection, 80% of the drug
will be systemically available
Somatropin/somatrem results and monitoring - answer✔✔Response to GH therapy is measured
every 3-6 months by height and bone age determinations
Somatropin/Somatrem Therapeutic use - answer✔✔Childhood Dwarfism/Growth hormone
deficiency disorders
Somatrem Drug class - answer✔✔Analog of GH; synthetic recombinant human growth hormone
with Extra amino acid noted in protein makeup
Somatrem MOA - answer✔✔Similar to somatropin
Octreotide Acetate and Lanreotide drug class - answer✔✔synthetic analogs of somatostatin
Octreotide Acetate and Lanreotide MOA - answer✔✔acts identical to somatostatin to directly
inhibit GH release from the anterior pituitary which effectively decreases circulating GH and
IGF-1 levels
Octreotide Acetate and Lanreotide Dosing - answer✔✔Long-acting depots allow for once-a-
month IM dosing due to gradual release formula (10-20 mg/4 weeks) T ½: 1-2 hours
Octreotide Acetate and Lanreotide Therapeutic effects - answer✔✔suppresses GH
hypersecretions, reduces pituitary adenoma overgrowth, and normalizing levels of GH and IGF-1
Octreotide acetate/Lanreotide/Pegvisomant Use - answer✔✔Acromegaly/Gigantism Tx
Pegvisomant Drug class - answer✔✔GH receptor antagonist
Pegvisomant MOA - answer✔✔Blocks actions of GH and reduces the levels of circulating IGF-
1
Pegvisomant Dosing - answer✔✔daily SubQ injections; increases dose until serum IGF-1 levels
are maintained to be within the age-appropriate/normal range (usually within 12 months, pt. Will
have normal or next to normal levels of IGF-1)
Pegvisomant drug structure - answer✔✔Extremely similar protein structure to GH but acts as a
receptor antagonist
Bromocriptine/Cabergoline drug class - answer✔✔Dopamine Receptor Agonists
Bromocriptine/Cabergoline MOA - answer✔✔Decreases prolactin production and secretions by
prolactin-secreting pituitary tumors; mimics the actions of dopamine and causes inhibition of
prolactin secretion
Bromocriptine/Cabergoline Pharmacokinetics - answer✔✔Orally Active and effective use in 80-
85% of cases
Bromocriptine/Cabergoline Therapeutic effects - answer✔✔Reduces tumor size, suppresses
galactorrhea and restores normal ovulatory menstrual cycles
Bromocriptine special consideration - answer✔✔Longer track record of safety in use and
cheaper to produce (DOC/more commonly used)
Cabergoline special consideration - answer✔✔Has higher reported affinity for D2 receptors
Desmopressin Drug Class - answer✔✔DDAVP/Vasopressin synthetic analog
Desmopressin MOA - answer✔✔activates V2 receptors in the kidney's collecting ducts,
reabsorbing water into plasma and concentrating the urine (prevents water from leaving the
body)
Desmopressin compared to ADH - answer✔✔Longer noted serum T ½ compared to ADH
(DDAVP t ½ = 75 min) (ADH t ½ = >10 min)
Desmopressin Structure - answer✔✔Almost identical to ADH except for D-Amino acid in
chemical chain sequence (ADH has L-Amino Acid) *NOTE: Has a greater selectivity for V2
receptors compared to typical ADH*
Desmopressin Outcomes of DI - answer✔✔Excessive urine production controlled with 0.1mg/3x
daily
Desmopressin Outcomes of Nocturnal Enuresis - answer✔✔4 months of Tx (0.2-0.4mg/daily)
will decrease average wet nights from 10/week to 6-7/2 weeks
Pitocin Drug class - answer✔✔Synthetic Oxytocin
Pitocin MOA - answer✔✔Stimulates uterine contractions during labor to strength (typically used
in induction/emergency scenarios if birth is taking an extremely long time)
Pitocin Pharmacokinetics - answer✔✔Given IV at low doses; used in OB/GYN practice
Hydrocortisone Drug class - answer✔✔glucocorticoid replacement therapy
Hydrocortisone MOA - answer✔✔mimics actions of cortisol (increasing gluconeogenesis,
protein, and lipid catabolism and body resistance response to stress)
Hydrocortisone Use - answer✔✔replacement therapies for both adrenal insufficiencies and anti-
inflammatory/immunosuppressive treatments (Glucocorticoid of choice in replacement tx since
adverse effects are minimized)
Hydrocortisone Pharmacokinetics - answer✔✔Short-acting drug ( t ½ 80 min that requires 2-3
doses/daily); The highest dose is an admin in the morning and smaller doses are given in the
evening to mimic natural cortisol blood levels // Short-acting preps are preferred because they
can be adjusted readily to reduce adverse effects and Extra doses can be given for bodily stresses
(infections, fever, injury)
Fludrocortisone Drug class - answer✔✔mineralocorticoid replacement therapy
Fludrocortisone MOA - answer✔✔mimics actions of aldosterone (salt retention and elimination
of K+; raises BP)
Fludrocortisone Use - answer✔✔Provides mineralocorticoid activity in replacement therapies for
adrenal insufficiencies
Fludrocortisone Pharmacokinetics - answer✔✔T ½ 18-36 hours (long-lasting) daily dose; dosing
is tailored to manage BP and fluid balances
Prednisone drug class - answer✔✔glucocorticoid replacement therapy
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