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PHCY 503_ClASS SESSION 1-7 STUDY SET EXAM
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PHCY 503_ClASS SESSION 1-7STUDY SET EXAM
Epinephrine: Drug Class - Answer Sympathomimetic Agent
Epinephrine: FDA-Approved Indications - Answer Anaphylaxis
Epinephrine: Brand Name - Answer Adrenalin
Epinephrine: Drug Target - Answer Adrenergic Receptors
Epinephrine: Normal Role/Physiology - Answer Alpha- and beta-adrenergic receptors
mediate vasoconstriction and vasodilation, respectively, as a result of the binding of
activation by norepinephrine and epinephrine, mediating cardiac function and blood
pressure homeostasis
Epinephrine: Pharmacologic Activity at Target - Answer Agonist
Epinephrine: Mechanism of Action - Answer Epinephrine stimulates alpha- and
beta-adrenergic receptors. Stimulation of alpha-adrenergic receptors induces
vasoconstriction. Stimulation of beta-adrenergic receptors in the bronchial tree induces
bronchodilation
Epinephrine: Therapeutic Effect - Answer Vasoconstriction from alpha-adrenergic
activation counteracts vasodilation and subsequent hypotension present during
anaphylactic shock, which in turn reduces heart rate. Bronchodilation reduces airway
obstruction to improve breathing
Aspirin: Drug Class - Answer Antiplatelet Agent, Salicylate; NSAID
Aspirin: FDA-Approved Indications - Answer Secondary prevention after acute coronary
syndrome (ACS)
Aspirin: Drug Target - Answer Cyclooxygenase-1 enzyme (COX-1)
Aspirin: Target Family and Location - Answer Oxidoreductase enzyme in platelets
Aspirin: Normal Role/Physiology - Answer COX-1 catalyzes the conversion of
arachidonic acid (AA) to prostaglandin H2 (PGH2). In platelets, PGH2 is then converted
to thromboxane A2 (TxA2), which is an autocrine and paracrine activator of platelet
aggregation during hemostasis
Aspirin: Mechanism of Action - Answer Aspirin irreversibly inhibits the platelet COX-1
enzyme to reduce formation of TxA2, thus blocking platelet aggregation
, Aspirin: Therapeutic Effect - Answer Reducing platelet aggregation will decrease
thrombus formation that could lead to ASCVD progression or a related cardiovascular
(CV) event
Aspirin: Pharmacologic Activity at Target - Answer Irreversible, competitive inhibitor
Ibuprofen: Drug class - Answer NSAID (non-steroidal anti-inflammatory drug)
NSAIDs: FDA-Approved Indication - Answer pain
NSAIDs: Drug Target - Answer Cox-1 and Cox-2 enzymes
NSAIDs: Target Family and Location - Answer oxidoreductase enzyme in platelets and
SMCs (COX-1) and parenchymal cells (COX-2)
NSAIDs: Normal role - Answer COX I and II stimulate the conversion of arachidonic acid
(AA) to PGH2, a precursor for prostanoids (prostaglandins and thromboxanes) which
mediate a variety of functions including inflammation, blood flow, fever, pain, uterine
contraction, GI motility, and more.
NSAIDs: Pharmacology Activity @ Target - Answer reversible competitve inhibitor
NSAIDs:MOA - Answer By reversibly inhibiting COX-1 and COX-2, NSAIDs inhibit the
biochemical conversion of arachidonic acid to PGH2 which then prevents the
downstream effects of prostanoids to prevent the inflammatory response and reduce
pain signalling
Name brand name
Diclofenac
Meloxicam
Naproxen
Celecoxib - Answer Voltaren
Mobic
Aleve
Celebrex
which NSAIDs targets only COX-2? - Answer Celecoxib (Celebrex)
Acetaminophen/Codeine: Brand Name - Answer Tylenol #3
Brand name: Methylprednisolone, Predisone - Answer Medrol, Depo-Medrol,
Solu-Medrol
Deltasone, Prednisone Intensol
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