Exam (elaborations)
NR 565 PHARMACOLOGY WEEK #4 EXAM QUESTIONS WITH COMPLETE ANSWERS
- Course
- Institution
NR 565 PHARMACOLOGY WEEK #4 EXAM QUESTIONS WITH COMPLETE ANSWERS
[Show more]
Content preview
NR 565 PHARMACOLOGY WEEK #4EXAM QUESTIONS WITH COMPLETE
ANSWERS
Most common inflammatory form of arthritis - Answer-Gout
Characteristics: RA - Answer-Rapid onset
3:1 in women/men
Age 35-50 years at onset
Affects hands and feet
local and systemic inflammation
60 mins morning joint stiffness
Symmetric
Elevated ESR
Leukocytosis
Systemic symptoms
RA symptoms - Answer-Pain
Swelling
Warmth
Stiffness
Characteristics: Osteoarthritis - Answer-Slow onset (years)
1:1 in men/women
Age > 50 years at onset
Affects hands, hips, knees
Mild or local inflammation
< 30 min morning joint stiffness
symmetric or asymmetric pattern
ESR normal
Mild leukocytosis
No systemic symptoms
Symptoms: Osteoarthritis - Answer-Pain
Bone enlargement
Treatment goals: RA - Answer-Relieve symptoms
Maintain joint function and ROM
Decrease systemic involvement
Delay disease progression
Medications: RA - Answer-NSAIDS
Glucocorticoids
, Conventional DMARDS
Biologic DMARDS
Mechanism of action: Conventional DMARDs - Answer-Immunosuppressant
Inhibits dihydrofolate reductase
Inhibits lymphocyte proliferation
Folate antagonist
Mechanism of action: Bioloic DMARDs - Answer-Inhibits JAK 1,2,3 = disruption of
cytokine and growth factor signaling pathways
Mechanism of action: Targeted DMARDs - Answer-Binds to and inhibits tumor necrosis
factor alpha = decreased inflammation and altered immune response
Medications: Conventional DMARDs - Answer-Methotrexate
Sulfasalazine (azulfidine)
Leflunomide (arava)
Hydroxychloroquine (plaquenil)
Medications: Biologic DMARDs - Answer-Adalimumab (Humira)
Certolizumab pegol (cimzia)
Etanercept (Enbrel)
Golimumab (Simponi)
Medications: Targeted DMARDs - Answer-Tofacitinib
Baricitinib
DMARD prescribing considerations - Answer-Obtain baseline CBC w/WBC differential
Assess for s/s of infection (TB/hepatitis) and malignancies
R/O pregnancy
Assess risk for immunocompetence (liver/renal status)
Comprehensive H+P to establish baseline
Screen for TB
Baseline diagnostic data: Conventional DMARDs - Answer-ALT, AST, serum creatinine
Baseline diagnostic data: Methotrexate - Answer-Chest x-ray, pulmonary + GI status
Baseline diagnostic data: Sulfasalazine - Answer-Chest x-ray, pulmonary + neurological
status
Baseline diagnostic data: Hydroxychloroquine - Answer-Ophthalmic exam, cardiac
exam w/ ECG
Baseline diagnostic data: Leflunomide - Answer-Chest x-ray, BP + pulmonary status
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller biggdreamer. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $13.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
71498 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now