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PHCY320 - Mens And Womens Health Study Set Exam
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PHCY320 - Mens And WomensHealth Study Set Exam
Mifepristone MOA - Answer Antiprogestational action as a result of competition with
progesterone at the progesterone receptors
Chronic Hypertension - Answer Systolic pressure ≥ 140 mmHg, diastolic pressure ≥90
mmHg, or both.
Presents before 20th week of pregnancy or persists longer then 12 weeks postpartum.
Gestational Hypertension - Answer Hypertension (diastolic blood pressure ≥ 90mmHg
OR systolic blood pressure ≥140 mmHg)
without any of the abnormalities that define pre-eclampsia
followed by return of blood pressure to normal within 3 months postpartum
Develops after 20 weeks gestation (was normotensive before this)
Gestational Hypertension antihypertensives? - Answer labetalol, nifedipine, methyldopa
Pre-eclampsia - Answer The new onset of hypertension after 20 weeks of gestation (in a
woman who was normotensive before 20 weeks of gestation)
and the coexistence of one or more of the following new-onset conditions:
Proteinuria (spot urine protein/creatinine ratio ≥30 mg/mmol or ≥2+ on dipstick testing
confirmed by a protein creatinine ratio test.
Other maternal organ dysfunction
Severe features of preeclampsia - Answer Severe hypertension, thrombocytopenia,
Impaired liver function, Progressive renal insufficiency
Preeclampsia treatment? - Answer Nifedipine, Labetalol IV or Hydralazine IV
Eclampsia - Answer New onset of seizures in association with pre- eclampsia.
Magnesium Sulphate - Answer - Calcium antagonist, its effect on vascular smooth
muscle to promote relaxation and vasodilation may have a role in lowering total
peripheral vascular resistance (lower blood pressure)
Cerebral endothelium to limit vasogenic edema by decreasing stress fiber contraction
(decrease fluid in the brain)
,Act centrally to inhibit NMDA receptors, providing anticonvulsant activity by increasing
the seizure threshold (reduce seizures)
Magnesium Sulphate toxicity? - Answer BURP: BP decrease, Urine output decrease,
Respiratory rate decrease, Patellar reflex absent
Reversal of Magnesium sulfate? - Answer Give Calcium gluconate as an antidote (slow
IV over ~10 minutes. 10mL of 10% solution)
Eclampsia cure? - Answer delivery
Pre medications for women with a high risk of pre-eclampsia? - Answer low dose aspirin
and calcium before 16 weeks' gestation
Target BG levels? - Answer Fasting and preprandial BG <5.0 mmol/L
1h postprandial BG <7.4 mmol/L
2h postprandial BG <6.7 mmol/L
GDM treatment? - Answer - Insulin
- Metformin
Estrogen in OCs? - Answer ethinylestradiol
More androgenic progesterones? - Answer - noresthisterone and levonorgestrel
less androgenic progesterones? - Answer desogestrel
Anti-androgenic progesterones? - Answer drospirenone and cyproterone
Health benefits of contraception? - Answer - Barrier effect, reduced ovarian and
endometrial cancer
Health risk of contraception? - Answer - Increased breast cancer, MI, ischemic stroke,
VTE
OC interactions? - Answer - AEDs: Carbamazepine phenobarbital phenytoin primidone
topiramate
- Rifampin
- St John's wort
- Antivirals HIV
- Lamotrigene increase
FOUR drug characteristics that facilitate drug molecule passage across a biological
membrane? - Answer Unionised, Lipophillic, No protein bound, MW <500 Da
, For a highly lipophilic drug would you expect the M/P ration to be high or low - Answer
High
Weakly acidic or basic drugs high conc in breast milk? - Answer Weakly basic drugs
typically have a higher concentration in breast milk than in plasma (M/P >1)
Since the pH of breast milk is lower than plasma, the degree of ionisation of a weak base
is higher on the breast milk side of the membrane.
4 Māori concepts? - Answer 1. WHAKAWHANAUNGATANGA
2. Aroha
3. KĀNOHI KITEA
4. MANAAKI TANGATA
5. Mana
6. MĀHAKI
7. Tikanga
Medication for post natal depression? - Answer Sertraline or escitalopram are currently
the most preferred (compatible with breastfeeding)
Oral Contraceptives Pharmacist Supply requirements? - Answer Pharmacists can sell
up to 6 months' OC supply to a woman who:
has been prescribed the same type of OC within the last 3 yrs from the date of an
original prescription,
& has not developed risk factors,
& are age 16 - 39 for COC or 16 - 52 for POP.
Pharmacist must have successfully completed PSNZ's OC training programme.
Only for selected OCs.
Unfunded
OC Adverse Effects? - Answer Nausea: Most common in 1st 3 months. Try taking at
night.
Breakthrough bleeding/spotting,Most common in 1st 3 months
Breast tenderness. Most common in 1st 3 months
Weight gain: May increase appetite in 1st month but little or no weight gain
Migraines: May increase or decrease. Avoid use if increased
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