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NR566 Final (Advanced Pharmacology for Care of the Family)Questions & Answers(RATED A) $14.99   Add to cart

Exam (elaborations)

NR566 Final (Advanced Pharmacology for Care of the Family)Questions & Answers(RATED A)

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Anti-Androgens - ANSWER Finasteride (Propecia) Leuprolide (Eligard, Lupron, Lupron Depot) Spironolactone (Aldactone) Finasteride (Propecia, Proscar) - ANSWER blocks conversion of testosterone to dihydrotesterone Used to tx: -BPH -male pattern baldness 3 months of therapy need to see...

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  • September 4, 2024
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  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • NR566
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NR566 Final (Advanced
Pharmacology for Care of the
Family)Questions &
Answers(RATED A)

Anti-Androgens - ANSWER Finasteride (Propecia)

Leuprolide (Eligard, Lupron, Lupron Depot)

Spironolactone (Aldactone)



Finasteride (Propecia, Proscar) - ANSWER blocks conversion of testosterone to dihydrotesterone



Used to tx:

-BPH

-male pattern baldness

3 months of therapy need to see benefits

Stopping, reverses effect w/in 12 months



Adverse side effects:

- Decreased libido

-Impotence



dutasteride (Avodart) - ANSWER 5-alpha reductase inhibitor

used to tx:

BPH

,Can stay in serum up to 6 mon after discontinuing



can be absorbed through skin

pregnant woman shouldn't handle capsules

(fetal anomaly in male fetus)



Adverse Effects

decreased libido

Impotence



Leuprolide Acetate (Lupron) - ANSWER Luteinizing hormone - releasing agonist

create reversible:

-orchiectomy state

-oophorectomy state



Used to tx:

- advanced prostatic cancer

- Management of endometriosis

- Uterine fibroids

- polycystic ovarian disease

- central precocious puberty in peds



Flutamide (Eulexin, Euflex) - ANSWER Truly non-steroidal agent

Used to tx:

-Advanced prostate cancer

-female androgen excess syndrome



Adverse Effects in males

- gynecomastia

-reversible liver toxicity

, Black Box Warning

-hepatic failure

-hepatic encephalopathy

Basline/monthly liver function test for 1st 4 months




Transdermal application of testosterone - ANSWER Patch + gel

can be applied to intact nonscrotal skin

once daily

not for use in woman

men cannot have skin contact with pregnant woman or children

Men need to wash hands after application + allow skin to dry



Testopel - ANSWER Subcu Pellet

produces testosterone for 3-6 months



Contraindications for Testosterone - ANSWER Male breast cancer

prostate cancer

Pregnancy (X category)

Lactation



Complications of Testosterone - ANSWER - Edema w/or w/out congestive heart failure

(use caution in pts w/ preexisting cardiac, renal, or hepatic disease)

Increased risk for

-prostatic hypertrophy

-prostatic hyperplasia

-prostatic carcinoma

Hypogonadal men might experience sleep apnea

This risk increases in men w/obesity or chronic lung disease.



Refer to endocrinologist - ANSWER stimulating growth in boys with delayed puberty

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