NR566 Week 6 CNS/Seizures
Questions &
Answers(GRADED A+)
Seizure medications work through 5 mechanisms including: - ANSWER Stop sodium influx
Stop Calcium influx
Promote potassium efflux
Antagonize glutamate
Potentiate Gamma-Aminobutyric Acid
Common adverse effects if Phenytoin (Dilantin) level >20mcg/mL include: - ANSWER Nystagmus
Sedation
Ataxia (staggering gait)
Diplopia (double vision)
Cognitive impairment
Common side effects of Phenytoin (Dilantin) - ANSWER Sedation and other CNS effects, nystagmus
(>20)
Gingival hyperplasia (oral hygiene & folic acid)
Morbilliform rash -> advance to SJS or TEN, Hypersensitivity with systemic involvement (DRESS) (X
HLA-B 1502 genetic mutation)
Cardiac dysrhythmias and hypotension (Slow IV injection)
Hirsutism
What is Phenytoin (Dilantin)? - ANSWER An anticonvulsant that is active against partial seizures and
primary generalized tonic-clonic seizures.
A selective sodium inhibitor
Therapeutic level of Phenytoin (Dilantin) - ANSWER 10-20 mcg/mL
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